Elsevier

Surgery

Volume 131, Issue 2, February 2002, Pages 216-218
Surgery

Brief Clinical Report
Sentinel lymph node biopsy demonstrating concomitant melanoma and mantle cell lymphoma*

https://doi.org/10.1067/msy.2002.115355Get rights and content

Abstract

Surgery 2002;131:216-8.

Section snippets

Case report

A 64-year-old man was diagnosed with mantle cell lymphoma in 1997. At that time, an examination of the cervical lymph node biopsy specimen revealed a non-Hodgkin lymphoma of the B-cell phenotype, with κ immunoglobulin light-chain restriction and positive expression of cyclin D1, which is characteristic of mantle cell lymphoma. Further radiographic workup revealed diffuse cervical, mediastinal, abdominal, and inguinal adenopathy. The results of the bone marrow biopsy were negative.

The patient

Discussion

To our knowledge, this is the first report of melanoma diagnosed as metastatic to a lymph node involved by another malignancy. Reports of other metastatic cancers in lymphomatous nodes lend credence to the idea that lymph node sampling for melanoma in patients with underlying lymphoma is feasible. Our patient had a collision tumor (ie, a single mass involving 2 distinct types of cancer). The simultaneous occurrence of 2 different neoplasms is uncommon, and collision tumors are even more

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*

Reprint requests: Barbara A. Pockaj, MD, Division of General Surgery, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259.

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