Brief Clinical ReportSentinel lymph node biopsy demonstrating concomitant melanoma and mantle cell lymphoma*
Section snippets
Case report
A 64-year-old man was diagnosed with mantle cell lymphoma in 1997. At that time, an examination of the cervical lymph node biopsy specimen revealed a non-Hodgkin lymphoma of the B-cell phenotype, with κ immunoglobulin light-chain restriction and positive expression of cyclin D1, which is characteristic of mantle cell lymphoma. Further radiographic workup revealed diffuse cervical, mediastinal, abdominal, and inguinal adenopathy. The results of the bone marrow biopsy were negative.
The patient
Discussion
To our knowledge, this is the first report of melanoma diagnosed as metastatic to a lymph node involved by another malignancy. Reports of other metastatic cancers in lymphomatous nodes lend credence to the idea that lymph node sampling for melanoma in patients with underlying lymphoma is feasible. Our patient had a collision tumor (ie, a single mass involving 2 distinct types of cancer). The simultaneous occurrence of 2 different neoplasms is uncommon, and collision tumors are even more
References (7)
- et al.
Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomised trial. WHO Melanoma Programme
Lancet
(1998) Metastatic squamous cell carcinoma of the skin occurring in a lymphomatous lymph node
J Am Acad Dermatol
(1985)- et al.
Long-term results of a multi-institutional randomized trial comparing prognostic factors and surgical results for intermediate thickness melanomas (1.0 to 4.0 mm)
Intergroup Melanoma Surgical Trial. Ann Surg Oncol
(2000)
Cited by (8)
Mantle cell lymphoma as a component of composite lymphoma: Clinicopathologic parameters and biologic implications
2012, Human PathologyCitation Excerpt :Given that (1) a subset of CLL/SLL cases shows CD23 negativity or aberrant expression of cyclin D1 within proliferation centers [37] and (2) 1 case of CLL/SLL-MCL (case 11) displayed only a few CD23+ B cells in the absence of pseudofollicles, although flow cytometry showed that 10% of lymph node cells were CD5−/CD23+high/Ig− B cells [15], pathologists attempting to pinpoint the type of lymphoma should be aware of such immunophenotypic variations and use an integrated approach to establish the correct diagnosis in the context of a CL, including detailed histopathologic analysis, immunophenotypic studies, cytogenetics, and molecular investigation. One case of CLL/SLL-MCL described by Addada et al [13] consisted of a metastatic melanoma and CLL/SLL-MCL together in a single lymph node, an extremely rare example of 3 synchronous tumor within the same anatomical compartment [38-40]. Five cases of CL consisting of MCL and cHL have been reported to date including 3 nodal, 1 extranodal (spleen), and 1 displaying nodal as well as extranodal (eyelid) involvement [17-21].
Cutaneous Involvement by Mantle Cell Lymphoma: Expanding the Spectrum of Histopathologic Findings in a Series of 9 Cases
2020, American Journal of DermatopathologyMelanoma and mantle cell lymphoma in a single collision tumor
2019, Baylor University Medical Center Proceedings“Double trouble” - Synchronous mantle cell lymphoma and metastatic squamous cell carcinoma in an inguinal lymph node
2017, Polish Journal of Pathology
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Reprint requests: Barbara A. Pockaj, MD, Division of General Surgery, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259.