Journal of Biological Chemistry
Volume 285, Issue 20, 14 May 2010, Pages 15356-15368
Cell BiologyNuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei*
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Phosphorylation/Kinases/Serine-Threonine
Signal Transduction/Protein Kinases/Serine/Threonine
Cell Division
Enzyme Kinetics
Parasitology
RNA Interference (RNAi)
Trypanosoma brucei
Cytokinesis
Drug Target
NDR Kinase
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This work was supported by Medical Research Council Career Development Fellowship G120/1001 (to T. C. H.), Medical Research Council New Investigator Research Grant G0900239 (to T. C. H.), Research Councils UK Academic Fellowship GR/T28003/01 (to T. C. H.), a Wellcome Trust Value in People award (to C. B.), and Wellcome Trust Strategic Award WT077705 (Drug Discovery for Tropical Disease Initiative).
The on-line version of this article (available at http://www.jbc.org) contains supplemental Table S1 and Figs. S1–S4.
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Both authors contributed equally to this work.
© 2010 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.