Journal of Biological Chemistry
EnzymologySET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*
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The atomic coordinates and structure factors (codes 3M53, 3M54, 3M55, 3M56, 3M57, 3M58, 3M59, and 3M5A) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
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This work was supported, in whole or in part, by National Institutes of Health Grant R01 GM073839 (to R. C. T.) and National Institutes of Health Administrative Supplement GM073839-04S1 (to R. C. T.) funded through the American Recovery and Reinvestment Act. This work was also supported by Department of Energy Grant DE-FG02-92ER20075 (to R. L. H.).
The on-line version of this article (available at http://www.jbc.org) contains supplemental Table 1.
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Supported by a Canadian Institutes of Health Research postdoctoral fellowship.