Journal of Biological Chemistry
Enzyme Catalysis and Regulation3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme*
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The atomic coordinates and structure factors (codes 2FBW, 1YQ3, and 1YQ4) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
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This work was supported in part by National Institutes of Health R01 Grants GM62563 and DK44842 and NIA, National Institutes of Health Grant PO1 AG15885. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The on-line version of this article (available at http://www.jbc.org) contains supplemental materials (parts S1–S8).
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Present address: Division of Bioorganic Chemistry and Molecular Pharmacology, Dept. of Internal Medicine, Washington University School of Medicine, Campus Box 8020, 660 South Euclid Ave., St. Louis, MO 63110.
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Present address: Ecole Superieure de Biotechnologie de Strasbourg, UMR7100 CNRS, Boulevard Sebastien Brant, BP 10413, 67412 Illkirch, France.