Journal of Biological Chemistry
Metabolism and BioenergeticsModest PGC-1α Overexpression in Muscle in Vivo Is Sufficient to Increase Insulin Sensitivity and Palmitate Oxidation in Subsarcolemmal, Not Intermyofibrillar, Mitochondria*
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This work was supported in part by grants from the Canadian Institutes of Health Research (to A. B. and T. G.), the Natural Sciences and Engineering Research Council of Canada (to A. B. and J. J. H.), the Netherlands Organization for Health Research and Development NWO-ZonMw Grant 40-00812-98-03075 (to J. L. and J. G.), the European Commission Integrated Project LSHM-CT-2004-005272, Exgenesis (to J. L. and J. G.), and the Canada Research Chair program (to J. J. H. and A. B.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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Supported by an Ontario graduate scholarship.
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Supported by an NSERC doctoral scholarship.
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Netherlands Heart Foundation Professor of Cardiac Metabolism.
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Recipient of a VIDI-Innovational Research Grant from the Netherlands Organization of Scientific Research NWO-ZonMw Grant 016.036.305.
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Canada Research Chair in Stress Protein Gene Research.