Journal of Biological Chemistry
Volume 284, Issue 16, 17 April 2009, Pages 10855-10867
Protein Synthesis, Post-Translational Modification, and DegradationMutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells*
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The abbreviations used are: HD, Huntington disease; Htt, huntingtin; poly(Q), polyglutamine; HEK, human embryonic kidney; N2a, Neuro-2a; NG108-15, neuroblastoma-glioma; PC12, pheochromocytoma; MS, mass spectrometry; LC, liquid chromatography; FITC, fluorescein isothiocyanate; BisTris, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol.
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This work was supported, in whole or in part, by National Institutes of Health Grants 16375 from the NINDS and NS038144-08. This work was also supported by the Huntington Disease Society of America Coalition for the Cure, High Q Foundation, Canadian Institutes of Health Research, and the HSC (Huntington Society of Canada).
© 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.