Minireviews
KAP1 Protein: An Enigmatic Master Regulator of the Genome*

https://doi.org/10.1074/jbc.R111.252569Get rights and content
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In mammalian cells, multiple cellular processes, including gene silencing, cell growth and differentiation, pluripotency, neoplastic transformation, apoptosis, DNA repair, and maintenance of genomic integrity, converge on the evolutionarily conserved protein KAP1, which is thought to regulate the dynamic organization of chromatin structure via its ability to influence epigenetic patterns and chromatin compaction. In this minireview, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mechanisms, protein-protein interactions, specific post-translational modifications of both KAP1 and associated histones, and transcriptome analyses of cells deficient in KAP1.

Chromatin Histone Modification
Chromatin Immunoprecipitation (ChIP)
Epigenetics
Transcription Factors
Transcriptional Repressor
Zinc Finger
ChIP-seq
KAP1
TIF1B
TRIM28

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*

This work was supported in part by United States Public Health Service Grants CA45240 and HG004558. This minireview will be reprinted in the 2011 Minireview Compendium, which will be available in January, 2012.