Biomarkers of Diseases & Conditions
The Role of Proteomics in Clinical Cardiovascular Biomarker Discovery

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Cardiovascular disease remains the most common cause of death in the developed world and is predicted by the World Health Organization to kill ∼20 million people worldwide each year until at least 2015. In light of these figures, work on producing superior tools for clinical use in the cardiovascular field is intensive. As proteins are the primary effectors of cellular function, a significant majority of this work focuses on the role of proteins in the cardiovascular system in physiological and pathological states in order to outline both mechanisms and markers of disease. One of the most effective ways to investigate these on a global basis is through proteomic analysis, which allows for broad spectrum screening of cellular protein or peptide complements during cardiovascular pathogenesis. Furthermore, specific technologies are now available to screen animal model or human blood samples for novel, improved markers of chronic disease states, such as atherosclerosis or for earlier indicators of acute myocardial stress, including ischemia/reperfusion injury and heart failure. This review summarizes current literature on the key aspects of proteomics and peptidomics related to clinical cardiovascular science.

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Published, MCP Papers in Press, July 30, 2008, DOI 10.1074/mcp.R800007-MCP200

This work was supported by a University of Sydney Research Grant (U1239). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

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Recipient of an Australian Postgraduate award.

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A National Health and Medical Research Council (NHMRC) CJ Martin Postdoctoral Fellow.