Leukemia mortality and occupational exposure to rubber: A nested case-control study

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Abstract

Objective – The excess risk of leukemia in rubber industry was considered to be real and attributed to the exposure to solvents, particularly benzene.

Methods – Following a nested case-control study, we used the data of 7 leukemia deaths in 1973 – 1997 and 28 controls matched for sex and age from the same cohort of a rubber plant. Leukemia risks due to exposure to rubber were assessed, unadjusted and adjusted for non-occupational factors by conditional logistic regression.

Results – OR for leukemia was found to be 7.81 (95%CI=0.77 – 78) in grouped analysis for one or more years of work in the inner tire tube department. The models for continuous exposure variables indicated that working for one year in the inner tire tube department was associated with a 10percent increment in the OR (955%CI=1.00 – 1.24; score test for linear trend: χ12=6.27, P=0.012). The confounding effects studied could not be ruled out for the excess risks. No excess risk was found in the remaining four departments.

Conclusions – Because of widespread exposure to various carcinogens in the process of making inner tire tubes, removal of a single agent (benzene) may not eliminate the risk of leukemia in the entire industry.

References (26)

  • E.W. Arp et al.

    L ymphocytic leukemia and exposures to benzene and other solvents in the rubber industry

    J Occup Med

    (1983)
  • L. Bernardinelli et al.

    Cancer mortality in an Italian rubber factory

    Br J Ind Med

    (1987)
  • N.E. Breslow et al.

    Statistical methods in cancer research Vol I. The analysis of case-control studies. 5th

    (1992)
  • G.L. Carlo et al.

    Reduced mortality among workers at a rubber plant

    J Occup Med

    (1993)
  • H. Checkoway et al.

    An evaluation of the associations of leukemia and rubber industry solvent exposures

    Am J Ind Med

    (1984)
  • G. Costa et al.

    Occupational mortality in Italy in the 80s

    (1995)
  • E. Delzell et al.

    Mortality among rubber workers:IX

    Curing workers. Am J Ind Med

    (1985)
  • E. Delzell et al.

    Mortality among rubber workers: VIII

    Industrial products workers. Am J Ind Med

    (1984)
  • U. Flodin et al.

    Chronic lymphatic leukemia and engine exhausts, fresh wood, and DDT:a case-referent study

    Br J Ind Med

    (1988)
  • Gallagher, R. P., Threlfall, W. J., Band, P.:Occupational mortality in British Columbia 1950–84. Cancer Control Agency...
  • P. Gustavsson et al.

    Mortality and incidence of cancer among Swedish rubber workers, 1952–81

    Scand J Work Environ Health

    (1986)
  • E. Heseltine

    International Agency for Research on Cancer monographs on the evaluation of the carcinogenic risk of chemicals to humans. Vol 28. The rubber industry

    (1982)
  • Z. Hrubec et al.

    Mortality risks by industry among US veterans of known smoking status 1954–1980

    (1995)
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