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Dietary fat influences Ia antigen expression, cytokines and prostaglandin E2 production of immune cells in autoimmune-prone NZB x NZW F1 mice

Published online by Cambridge University Press:  09 March 2007

Bi-Fong lin ,
Chao-Chi Huang ,
Bor-Luen Chiang  and
Su-Jen Jeng
Bi-Fong lin
Affiliation:
Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, College of Agriculture
Chao-Chi Huang
Affiliation:
Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, College of Agriculture
Bor-Luen Chiang
Affiliation:
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan 10764, Republic of China
Su-Jen Jeng
Affiliation:
Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, College of Agriculture
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Abstracts

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To elucidate further the influences of dietary fat on autoimmune diseases, two groups of NZB/W F1 mice were fed with diets containing 200 g dietary fat/kg and 50 g dietary fat/kg (control) respectively. The difference in energy intake between these two groups was compensated with carbohydrate. Mice were bled regularly every month and some of them were killed for in vitro experiments after 5 months experimental diets. Higher immunoglobulin (Ig)M and IgG anti-double stranded DNA antibody levels, shortened life span and worsened proteinuria were noted in mice fed on the high-fat diet compared with those fed on 50g dietary fat/kg. Phenotypic analyses of spleen cells and peritoneal exudate cells showed that the percentage of CD5+ B cells and the mean fluorescent intensity of major histocompatibility molecules on the surface of both types of cells were higher in mice fed on the high-fat diet. In general, higher type 2 T-helper cell activity was noted in mice fed on the high-fat diet. In addition, cytokines such as interleukin-6, tumour necrosis factor-α and prostaglandin E2 (PGE2) produced by lipopolysaccharide-stimulated peritoneal exudate cells were also higher in the high-dietary-fat group. These studies suggest that high dietary fat and its related PGE2 level might have a critical effect on the frequency of CD5+ B cells, cytokine production, macrophage function and subsequent autoimmune regulation in autoimmune mice.

Keywords

Systemic lupus erythematosusAutoimmunityCD5+ B cellsCytokinesProstaglandins
Type
Fat nutrition and autoimmunity
Information
British Journal of Nutrition , Volume 75 , Issue 5 , May 1996 , pp. 711 - 722
Copyright
Copyright © The Nutrition Society 1996

References

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