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Lipid atherogenic risk markers can be more favourably influenced by the cis-9,trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters

Published online by Cambridge University Press:  09 March 2007

Karine Valeille ,
Daniel Gripois ,
Marie-France Blouquit ,
Maamar Souidi ,
Michel Riottot ,
Jean-Christophe Bouthegourd ,
Colette Sérougne  and
Jean-Charles Martin
Karine Valeille
Affiliation:
ARILAIT Recherches, 42 rue de Châteaudun, 75314 Paris, Cedex 09, France
Daniel Gripois
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Marie-France Blouquit
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Maamar Souidi
Affiliation:
Institut de Radioprotection et de Sûreté Nucléaire, SARAM/DPHD, rue Auguste Lemaire, IRSN, BP 17, 92262 Fontenay-aux-Roses, Cedex, France
Michel Riottot
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Jean-Christophe Bouthegourd
Affiliation:
UMR INRA/INA P-G 914, Physiologie de la Nutrition et du Comportement Alimentaire, 16 rue Claude Bernard, 75231 Paris, Cedex 05, France
Colette Sérougne
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Jean-Charles Martin*
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
*
*Corresponding author: Dr Jean-Charles Martin, fax +33 1 69 15 70 74, email jean-charles.martin@ibaic.u-psud.fr
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Abstract

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The aim of our present study was to compare the efficiency of conjugated linoleic acids (CLA) and fish oil in modulating atherogenic risk markers. Adult male hamsters were given a cholesterol-rich diet (0·6 g/kg) for 8 weeks; the diet was supplemented with 5 g cis-9,trans-11-CLA isomer/kg, 12 g CLA mixture (CLA-mix)/kg, 12 g fish oil/kg or 12 g fish oil + 12 g CLA-mix/kg. The plasma cholesterol status was improved only with the cis-9,trans-11-CLA (HDL-cholesterol and HDL-cholesterol:LDL-cholesterol ratio, P<0·05), but was of borderline significance for CLA-mix (HDL-cholesterol:LDL-cholesterol ratio, P=0·06), with an increase (33–40 %) in the liver lipoprotein receptors (scavenger receptor-type I and LDL ApoB/E receptor) and HDL-binding protein 2 (P<0·05). A 100 % pigment gallstones incidence and a slight insulin resistance (homeostatic model assessment index) were observed in the CLA-mix-fed hamsters (P=−0·031). In comparison, fish-oil feeding alone improved merely the scavenger receptor-type I and HDL-binding protein 2 liver status and faeces sterol output. For most of our present observations, the concomitant intake of fish oil and CLA-mix gave dominant effects that were exclusive and specific to one or the other oil. In conclusion, part of the beneficial effects of CLA in the present study can be ascribed to the cis-9,trans-11-isomer, and these did not generally overlap with those of fish oil. In addition, the CLA-mix effects are clearly affected by the marine (n-3) fatty acids.

Keywords

Conjugated linoleic acidRumenic acidFish oilLipid atherosclerosis risk markersHamsters
Type
Research Article
Information
British Journal of Nutrition , Volume 91 , Issue 2 , February 2004 , pp. 191 - 199
Copyright
Copyright © The Nutrition Society 2004

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