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Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract

Published online by Cambridge University Press:  08 March 2007

Daniela E. Marin ,
Ionelia Taranu ,
Florentina Pascale ,
Alexandru Lionide ,
Radu Burlacu ,
Jean-Denis Bailly  and
Isabelle P. Oswald
Daniela E. Marin
Affiliation:
Laboratoire de Pharmacologie-ToxicologieUR 66Institut National de la Recherche AgronomiqueToulouseFrance IBNAInstitute of Biology and Animal NutritionBalotestiRomania
Ionelia Taranu
Affiliation:
Laboratoire de Pharmacologie-ToxicologieUR 66Institut National de la Recherche AgronomiqueToulouseFrance IBNAInstitute of Biology and Animal NutritionBalotestiRomania
Florentina Pascale
Affiliation:
Pasteur InstituteBucharestRomania
Alexandru Lionide
Affiliation:
IBNAInstitute of Biology and Animal NutritionBalotestiRomania
Radu Burlacu
Affiliation:
Institute of the Bovine Research DevelopmentBalotestiRomania
Jean-Denis Bailly
Affiliation:
Ecole Nationale VétérinaireToulouseFrance
Isabelle P. Oswald*
Affiliation:
Laboratoire de Pharmacologie-ToxicologieUR 66Institut National de la Recherche AgronomiqueToulouseFrance
*
*Corresponding author: Dr Isabelle P. Oswald, fax +33 5 61 28 53 10, email ioswald@toulouse.inra.fr
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Abstract

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Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium verticillioides, a fungus that commonly contaminates maize. Sex-related effects of FB1 have been observed with respect to carcinogenicity in rodents, to performances in pigs and immunosuppression in mice. In the present study the sex-related effect of FB1 on the pig immune response was determined. Female and castrated male piglets received for 28d either control feed or feed contaminated with 8mg FB1/kgfeed in the form of F. verticillioidesculture material. At day 7 and day 21, animals were immunised subcutaneously with a Mycoplasma agalactiae vaccine. Ingestion of FB1-contaminated feed significantly decreased weight gain in males but had no effect in females. No sex-related difference was observed in biochemical parameters, but a higher level of creatinine was noted in toxin-treated animals. FB1 also altered the pig immune response in a sex-specific manner. In males, ingestion of FB1-contaminated feed significantly decreased specific antibody levels after vaccination as well as the mRNA expression level of IL-10. In females, the toxin has no effect on specific antibodies or on cytokine mRNA levels. The results of the present study indicatethat FB1 is immunosuppressive in pigs. The magnitude of this FB1-induced immunosuppression is highly dependent on sex, with males being more susceptible than females.

Keywords

FumonisinMycotoxinsImmunosuppressionFood contaminationPigGender-related effects
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 6 , June 2006 , pp. 1185 - 1192
Copyright
Copyright © The Nutrition Society 2006

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