p63 is useful in the diagnosis of mammary metaplastic carcinomas
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Spindle cell lesions of the breast: diagnostic issues
2020, Diagnostic HistopathologyCitation Excerpt :In biphasic metaplastic carcinomas, the defining carcinomatous component is most commonly glandular (infiltrating duct carcinoma) (Figures 6a, 6b) but can also be squamous or carcinoma-in-situ.65 The sarcomatous component usually retains at least focal immunohistochemical evidence of epithelial origin, which can be demonstrated by cytokeratin cocktails and p63.66 Positivity to myoepithelial markers (SMA, S-100) can also be seen in some metaplastic carcinomas.65
Diagnostic Pathology: Breast
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