Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

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Summary

A genome scan of ∼12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

Bipolar disorder
Linkage
Genome scan
Manic depression
Human
Behavioral genetics

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Present affiliation: Lawrence Berkeley National Laboratory, Berkely, CA.

Present affiliation: Mayo Clinic, Rochester, MN.

Present affiliation: Whitehead Institute for Biomedical Research, Cambridge, MA.

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Present affiliation: University of Chicago, Chicago.

Present affiliation: University of Maryland School of Medicine, Baltimore.

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Present affiliation: Genomica Corporation, Boulder, CO.