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Psychotropic and Anticonvulsant Drugs in Subjects with Autism: Prevalence and Patterns of Use

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ABSTRACT

Objective

To survey the prevalence and patterns of psychotropic and anticonvulsant medication and vitamin treatments in patients with autism.

Method

Caregivers of 1,595 index cases were sent survey questionnaires by mail, and repeat questionnaires were sent twice if no reply was received.

Results

A total of 838 care providers (53%) responded to the survey. In all, 33.8% of the sample was taking some psychotropic drug or vitamin for autism or associated behavioral/psychiatric problems. A total of 19.2% reported having epilepsy, but only 13.2% were taking anticonvulsant drugs. More than 50% of the sample was taking some psychotropic, antiepileptic, vitamin, or “medical” agent. Of the agents taken, care providers were most satisfied with anticonvulsants, antidepressants, and stimulants. The use of each drug group was analyzed with respect to subject and demographic variables to evaluate medication patterns within this population.

Conclusion

As in the often related clinical population of mental retardation, psychotropic medication appears to be heavily used in patients with autism.

REFERENCES (32)

  • E Babbie

    The Practice of Social Research

    (1992)
  • M Campbell

    Pharmacotherapy in autism: an overview

  • M Campbell et al.

    Psychopharmacological treatment

  • M Campbell et al.

    Response to triiodothyronine and dextroamphetamine: a study of preschool schizophrenic children

    J Autism Child Schizophr

    (1972)
  • M Campbell et al.

    Levodopa and levoamphetamine: a crossover study in young schizophrenic children

    Curr Ther Res

    (1976)
  • RO Carpenter et al.

    Antiepileptics (anticonvulsants)

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    This work was supported in part by NIMH research grant MH 44122 to Dr. Aman. The authors thank Sharon Van Fossen and Anthony Allen for practical assistance in this study and Mr. Alistair Stewart (Auckland University) and Dr. John Spicer (Massey University) for guidance on the logistic regression analyses.

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