Regular Research ArticlesTest Characteristics of the 15-Item Geriatric Depression Scale and Hamilton Depression Rating Scale in Parkinson Disease
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Subjects
The study population consisted of a convenience sample of 148 outpatients, all (but two) male, who were new or established patients at the Parkinson's Disease Research, Education and Clinical Center (PADRECC) at the Philadelphia Veterans Affairs Medical Center (PVAMC) or the Parkinson's Disease and Movement Disorders Center (PDMDC) at the University of Pennsylvania. The PVAMC and University of Pennsylvania Institutional Review Boards approved the study, and only patients able to provide
RESULTS
Characteristics of the sample population included: mean age=72.0 years (standard deviation [SD]: 8.5, range: 40–90), MMSE score=27.5 (SD: 2.6, range: 13–30), duration of PD=7.8 years (SD: 5.8, range: 1–25), UPDRS score=24.5 (SD: 11.5, range: 3–60), Hoehn and Yahr stage = 2.3 (SD: 0.6, range: 1–4), and mean daily L-dopa dosage = 440 mg (SD: 322 mg, range: 0–1420 mg). Thirty-two subjects (21.6%) met DSM–IV diagnostic criteria for a depressive disorder (18 [12.2%] with major depression and 14
DISCUSSION
The GDS-15 is a commonly used instrument for depression screening in the general geriatric population and has been piloted for use in PD as well.31 Its clinical use in identifying depressed patients and its usefulness as a research tool for dPD, however, are predicated on the assumption that the GDS-15 is a valid measure of depression in this population. We evaluated the psychometric properties of the GDS-15 against the “gold standard” of DSM–IV criteria for a depressive disorder and compared
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This study was supported by a grant from National Institute of Mental Health (#K23MH067894).