Journal of the American Academy of Child & Adolescent Psychiatry
ARTICLESEffects of Methylphenidate on Subtypes of Attention-Deficit/Hyperactivity Disorder
Section snippets
ADHD Subtypes
Although the ADHD/inattentive (ADHD/I) subtype is more prevalent in the population than ADHD/combined (ADHD/C; Baumgaertel et al., 1995), ADHD/C is more common in clinical populations (Faraone et al., 1998). In addition, greater excess of boys among ADHD/C than ADHD/I children has been reported in population studies (Carlson and Mann, 2000), but not universally in clinical samples (Faraone et al., 1998). There are mixed findings concerning an excess of learning disabilities (Faraone et al., 1998
Participants
The protocol was approved by the University of Rochester's Research Subjects Review Board. Informed consent procedures were followed. We studied 19 children with ADHD/I, 22 children with ADHD/C and 34 community controls. Two additional children with ADHD children entered the pharmacological trial but withdrew during their second phase (placebo and methylphenidate, respectively) and were not included in the results. Children in all samples met these criteria: ages 6 to 12; WISC-III (Wechsler,
Analytic Strategy
Continuous variables were submitted to analyses of variance with diagnosis (or subtype, as indicated) and drug order as between-subject factors and sessions (or trial phases, as appropriate) as a within-subjects factor. For these analyses, controls were assigned to pseudo drug order groups that were comparable in age and gender, respectively, to ADHD children who received each of the drug sequences. Effect sizes are reported as η2p (partial η2). Omnibus F tests were followed by pairwise
Arithmetic
At the baseline and placebo sessions, controls exceeded children with ADHD/I in correct arithmetic solutions. There was also a nonsignificant trend for superior performance by controls over children with ADHD/C in the baseline session. Consistent with previous findings (Barkley et al., 1990, Faraone et al., 1998), no differences in arithmetic performance were obtained between the two ADHD subtypes. Notably, the arithmetic test reflects not absolute arithmetic competence, but performance at
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Funding was provided by National Institute of Mental Health grant MH56571.
The authors thank Virginia Douglas, Ph.D., and Rosemary Tannock, Ph.D., for providing research instruments; Loisa Bennetto, Ph.D., for comments; H. Theresa Chang, Ph.D., Nora Ilniczky, Ph.D., and Helena Kopecky, Ph.D., for testing subjects; Chad Swenson, B.S.Pharm., for monitoring the pharmacological trial; and Thomas Olshan, B.A., Melissa Sturtz-Verastegui, B.A., and Laura Young, B.A., for scoring help.
Disclosure: The authors have no financial relationships to disclose.