Regular Research ArticlesReduced Prefrontal Oxygenation in Alzheimer Disease During Verbal Fluency Tasks
Section snippets
Subjects
The NIRS-measurement on patients and healthy participants was in accordance with the Declaration of Helsinki, Finland, and approved by the Ethical Committee of the University of Wuerzburg. Sixteen patients with dementia (5 male and 11 female) and a healthy control group (6 male and 10 female) were investigated after giving written informed consent. The mean age was 69.5 ± 8.4 years for the patients and 67.9 ± 5.4 years for the comparison group (t(30) <1, p = 0.53).
The patients were inpatients
Behavioral Data
Dementia patients had a significantly worse behavioral performance for the letter (10.0 ± 5.6; t(30) = 4.9, p <0.001) as well as the category version (16.1 ± 5.5; t(30) = 9.6, p <0.001) of the VFT compared to the control group (letter version: 19.8 ± 5.8; category version: 33.6 ± 4.8).
Letter Version of the VFT
In the letter version of the VFT, we found significant main effects related to the factors channels (F(3.00, 90.05) = 6.68, p <0.001) and time (F(1, 3 0) = 11.1, p <0.01) for HHb. Additionally, the interaction
DISCUSSION
In the category and letter versions of the VFT, both the dementia and control groups displayed an increase of O2Hb and a decrease of HHb, which is considered to be the typical NIRS pattern during activation. In both conditions, the increase in O2Hb was more pronounced for the healthy comparison group than for dementia patients, whereas no general differences concerning diagnosis were found for HHb.
As previously described,23 the HHb reduction occurred mainly over superior sensor positions in the
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This work was supported by a grant from the Alzhe-imer Forschung Initiative (to A.J.F.).
The authors thank Hitachi Medical Corporation for the ETG-100 equipment and technical support and Mrs. Groebner for dedicated assistance in data recording.