Regular Research ArticlesOne-Year Change in Anterior Cingulate Cortex White Matter Microstructure: Relationship With Late-Life Depression Outcomes
Section snippets
Sample
Participants were initially recruited via advertisements and outpatient clinical referrals at Duke University Medical Center to participate in a 12-week study examining the relationship among hyperin-tense lesions, cognition, and 12-week response to sertraline.18, 19 Entry criteria for this parent study included meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for major depressive disorder (MDD) without psychosis by the Structured Clinical
RESULTS
As previously reported,18 74 depressed subjects enrolled in the original 12-week trial of sertraline had evaluable DTI data. Thirty-six of those subjects either refused to participate in this follow-up study or were lost to follow-up. Of the 38 individuals who did enroll, DTI scan data were not processable for nine individuals, primarily because the MRI being ended early or difficulties with image registration. This resulted in a sample of 29 individuals who were depressed at entry into the
DISCUSSION
Our primary finding was that the cohort of subjects who were depressed at study entry and did not remit over the following 1-year period exhibited less change in ACC white matter FA than did either nondepressed subjects or depressed subjects who remitted. There was no significant difference in ACC FA change between the nondepressed and remitted subjects. Moreover, we found a statistically significant positive correlation between change in ACC FA and change in MADRS score over 1 year, wherein a
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Cited by (0)
We acknowledge Cynthia R. Key for preparing and preprocessing of DTI data and Kulpreet Singh for assistance with the figure.
This work was supported by NIMH grants R01 MH078216 and R01 MH074916.
Drs. Taylor and MacFall and Mr. Boyd have no conflicts to report. Dr. Payne has received speaking honoraria from Eli Lilly (Taiwan). Dr. Sheline reports serving on the Eli-Lilly Speakers Bureau. Dr. Krishnan has received consultancy fees from CeNeRx, Corcept, Glaxo-SmithKline, Johnson & Johnson, Merck, Roche, and Son-exa. He has ownership interest in Orexigen, CeNeRx, and Sonexa. Dr. Doraiswamy has received research grants and honoraria for consulting or speaking from several pharmaceutical companies and antidepressant manufacturers and has stock in Sonexa Therapeutics.