Elsevier

Journal of Thoracic Oncology

Volume 3, Issue 11, November 2008, Pages 1272-1278
Journal of Thoracic Oncology

Original Article
Adjuvant Chemotherapy Uptake in Non-small Cell Lung Cancer

https://doi.org/10.1097/JTO.0b013e318189f562Get rights and content
Under an Elsevier user license
open archive

Introduction

Adjuvant chemotherapy in non-small cell lung cancer (NSCLC) has become a new standard of care. This study examines the uptake patterns for adjuvant chemotherapy outside of clinical trials.

Methods

A retrospective study of all patients diagnosed with NSCLC in the year 2005 who underwent curative-intent surgery in Nova Scotia, Canada was conducted. Logistic regression models and discriminant function analyses were employed to identify cofactors associated with referral to medical oncology and/or utilization of adjuvant chemotherapy.

Results

Of 540 patients with NSCLC, 108 underwent curative-intent surgery (67% lobectomy; 15% pneumonectomy; 19% wedge resection) for NSCLC (39% IA; 24% IB; 25% II; 14% III). Referral to medical oncology was observed in 44% (47 of 108) of all patients including 73% (30 of 41) of those with stage II–III. Adjuvant chemotherapy utilization was observed in 62% (29 of 47) of those referred including 73% (22 of 30) of those with stage II–III. Overall, 27% (29 of 108) of all patients received adjuvant chemotherapy, including 54% (22 of 41) of those with stage II–III. Higher uptake was significantly associated with age (younger versus older), stage (II/III versus I), and surgery type (pneumonectomy versus wedge). Weaker associations were observed with other cofactors including surgeon, health center, mean household income, and surgery-medical oncologist consult timeline.

Conclusions

The uptake of adjuvant chemotherapy in patients with resected NSCLC outside of clinical trials is low overall, but is higher among younger patients and those with more advanced stages. These uptake patterns may allow future planning of health resource utilization and/or improvement of chemotherapy utilization rates.

Key Words

Non-small cell lung cancer
Adjuvant chemotherapy
Treatment uptake

Cited by (0)

Disclosure: The authors declare no conflicts of interest.

Supported by Surveillance and Epidemiology Unit and the Lung Cancer Site Team of Cancer Care Nova Scotia.

Presented as a poster presentation at the 2007 annual meeting of the American Society of Clinical Oncology in Chicago, USA.