1887

Abstract

Thirteen patients with leptospirosis were identified, as confirmed by laboratory analysis during the last 5 years in our laboratory, who came from urban areas of Tokyo, Japan. All of the patients came into contact with rats before the onset of illness. Seventeen per cent of Norway rats captured in the inner cities of Tokyo carried leptospires in their kidneys. Most of these rat isolates were serovar Copenhageni/Icterohaemorrhagiae. Antibodies against these serovars and their DNA were detected in the patients. This suggests that rats are important reservoirs of leptospirosis, and that rat-borne leptospires occur in urban areas of Tokyo.

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2009-09-01
2024-03-29
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References

  1. Ariyapruchya B., Sungkanuparph S., Dumrongkitchaiporn S. 2003; Clinical presentation and medical complication in 59 cases of laboratory-confirmed leptospirosis in Bangkok. Southeast Asian J Trop Med Public Health 34:159–164
    [Google Scholar]
  2. Bharti A. R., Nally J. E., Ricaldi J. N., Matthias M. A., Diaz M. M., Lovett M. A., Levett P. N., Gilman R. H., Willig M. R. & other authors; 2003; Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3:757–771 [CrossRef]
    [Google Scholar]
  3. Demers R. Y., Frank R., Demers P., Clay M. 1985; Leptospiral exposure in Detroit rodent control workers. Am J Public Health 75:1090–1091 [CrossRef]
    [Google Scholar]
  4. Doungchawee G., Phulsuksombat D., Naigowit P., Khoaprasert Y., Sangjun N., Kongtim S., Smythe L. 2005; Survey of leptospirosis of small mammals in Thailand. Southeast Asian J Trop Med Public Health 36:1516–1522
    [Google Scholar]
  5. Easterbrook J. D., Kaplan J. B., Vanasco N. B., Reeves W. K., Purcell R. H., Kosoy M. Y., Glass G. E., Watson J., Klein S. L. 2007; A survey of zoonotic pathogens carried by Norway rats in Baltimore, Maryland, USA. Epidemiol Infect 135:1192–1199
    [Google Scholar]
  6. Faine S., Adler B., Bolin C., Perolat P. 1999 Leptospira and Leptospirosis , 2nd edn. Melbourne: MediSci;
    [Google Scholar]
  7. Herrmann J. L., Baril C., Bellenger E., Perolat P., Baranton G., Saint Girons I. 1991; Genome conservation in isolates of Leptospira interrogans . J Bacteriol 173:7582–7588
    [Google Scholar]
  8. Herrmann J. L., Bellenger E., Perolat P., Baranton G., Saint Girons I. 1992; Pulsed-field gel electrophoresis of Not I digests of leptospiral DNA: a new rapid method of serovar identification. J Clin Microbiol 30:1696–1702
    [Google Scholar]
  9. Johnson M. A. S., Smith H., Joseph P., Gilman R. H., Bautista C. T., Campos K. J., Cespedes M., Klatsky P., Vidal C. other authors 2004; Environmental exposure and leptospirosis, Peru. Emerg Infect Dis 10:1016–1022 [CrossRef]
    [Google Scholar]
  10. Kawabata H., Dancel L. A., Villanueva S. Y., Yanagihara Y., Koizumi N., Watanabe H. 2001; fla B-polymerase chain reaction ( fla B-PCR) and its restriction fragment length polymorphism (RFLP) analysis are an efficient tool for detection and identification of Leptospira spp. Microbiol Immunol 45:491–496 [CrossRef]
    [Google Scholar]
  11. Ko A. I., Galvão Reis M., Ribeiro Dourado C. M., Johnson W. D. Jr, Riley L. W. 1999; Urban epidemic of severe leptospirosis in Brazil. Lancet 354:820–825 [CrossRef]
    [Google Scholar]
  12. Kobayashi Y., Tamai T., Oyama T., Hasegawa H., Sada E., Kusaba T., Hamaji M. 1984; Characterization of monoclonal antibodies against etiological agents of Weil's disease. Microbiol Immunol 28:359–370 [CrossRef]
    [Google Scholar]
  13. Koizumi N., Watanabe H., Umezawa K., Iiduka T., Inokuchi S. 2003; A case of leptospirosis diagnosed early by flaB -PCR. Kansenshogaku Zasshi 77:627–630 (in Japanese [CrossRef]
    [Google Scholar]
  14. Koizumi N., Muto M., Yamamoto S., Baba Y., Kudo M., Tamae Y., Shimomura K., Takatori I., Iwakiri A. other authors 2008; Investigation of reservoir animals of Leptospira in the northern part of Miyazaki prefecture. Jpn J Infect Dis 61:465–468
    [Google Scholar]
  15. Koizumi N., Uchida M., Makino T., Taguri T., Kuroki T., Muto M., Kato Y., Watanabe H. 2009; Isolation and characterization of Leptospira spp. from raccoons in Japan. J Vet Med Sci 71:425–429 [CrossRef]
    [Google Scholar]
  16. Krøjgaard L. H., Villumsen S., Markussen M. D. K., Jensen J. S., Leirs H., Heiberg A.-C. 2009; High prevalence of Leptospira spp.in sewer rats ( Rattus norvegicus ). Epidemiol Infect in press [View Article]
    [Google Scholar]
  17. LaRocque R. C., Breiman R. F., Ari M. D., Morey R. E., Janan F. A., Hayes J. M., Hossain M. A., Brooks W. A., Levett P. N. 2005; Leptospirosis during dengue outbreak, Bangladesh. Emerg Infect Dis 11:766–769 [CrossRef]
    [Google Scholar]
  18. Levett P. N. 2001; Leptospirosis. Clin Microbiol Rev 14:296–326 [CrossRef]
    [Google Scholar]
  19. McBride A. J. L., Athanazio D. A., Reis M. G., Ko A. I. 2005; Leptospirosis. Curr Opin Infect Dis 18:376–386 [CrossRef]
    [Google Scholar]
  20. Nakamura M., Taira K., Itokazu K., Kudaka J., Asato R., Kise T., Koizumi N. 2006; Sporadic cases and an outbreak of leptospirosis probably associated with recreational activities in rivers in the northern part of Okinawa Main Island. J Vet Med Sci 68:83–85 [CrossRef]
    [Google Scholar]
  21. Narita M., Fujitani S., Haake D. A., Paterson D. L. 2005; Leptospirosis after recreational exposure to water in the Yaeyama Islands, Japan. Am J Trop Med Hyg 73:652–656
    [Google Scholar]
  22. Tangkanakul W., Tharmaphornpil P., Plikaytis B. D., Bragg S., Poonsuksombat D., Choomkasien P., Kingnate D., Ashford D. A. 2000; Risk factors associated with leptospirosis in northeastern Thailand, 1998. Am J Trop Med Hyg 63:204–208
    [Google Scholar]
  23. Vinetz J. M., Glass G. E., Flexner C. E., Mueller P., Kaslow D. C. 1996; Sporadic urban leptospirosis. Ann Intern Med 125:794–798 [CrossRef]
    [Google Scholar]
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