Nuclear Functions of Actin
- 1Department of Molecular Biology & Functional Genomics, Stockholm University, SE-106 91, Stockholm, Sweden
- 2Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden
- Correspondence: Neus.Visa{at}molbio.su.se and Piergiorgio.Percipalle{at}ki.se
Abstract
Actin participates in several essential processes in the cell nucleus. Even though the presence of actin in the nucleus was proposed more than 30 years ago, nuclear processes that require actin have been only recently identified. Actin is part of chromatin remodeling complexes; it is associated with the transcription machineries; it becomes incorporated into newly synthesized ribonucleoproteins; and it influences long-range chromatin organization. As in the cytoplasm, nuclear actin works in conjunction with different types of actin-binding proteins that regulate actin function and bridge interactions between actin and other nuclear components.
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