Early-replicating heterochromatin
Abstract
Euchromatin, which has an open structure and is frequently transcribed, tends to replicate in early S phase. Heterochromatin, which is more condensed and rarely transcribed, usually replicates in late S phase. Here, we report significant deviation from this correlation in the fission yeast, Schizosaccharomyces pombe. We found that heterochromatic centromeres and silent mating-type cassettes replicate in early S phase. Only heterochromatic telomeres replicate in late S phase. Research in other laboratories has shown that occasionally other organisms also replicate some of their heterochromatin in early S phase. Thus, late replication is not an obligatory feature of heterochromatin.
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Footnotes
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↵3 Corresponding author.
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E-MAIL joel.huberman{at}roswellpark.org; FAX (716) 845-8126.
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Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1046203.
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- Received October 1, 2002.
- Accepted November 27, 2002.
- Cold Spring Harbor Laboratory Press