Eating to exit: autophagy-enabled senescence revealed

Eileen White; Scott W. Lowe

doi:10.1101/gad.1795309

Eating to exit: autophagy-enabled senescence revealed

Eileen White1,2,4 and
Scott W. Lowe1,3,5

¹The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA;
²Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;
³Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA

Abstract

Autophagy and senescence are two distinct cellular responses to stress that are also tumor suppression mechanisms. In this issue of Genes & Development, Young and colleagues (pp. 798–803) discovered that autophagy is induced during and facilitates the process of senescence. Knowing now that these two pathways are functionally intertwined sets the stage for establishing how they function cooperatively in the cancer setting.

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Footnotes

↵4 Correspondence.

↵E-MAIL eileenpwhite{at}gmail.com or whiteei{at}umdnj.edu; FAX (732) 325-5795.
↵5 E-MAIL lowe{at}cshl.edu; FAX (516) 367-8454.
Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1795309.