Paused Pol II captures enhancer activity and acts as a potent insulator
Abstract
Enhancers act over many kilobase pairs to activate target promoters, but their activity is constrained by insulator elements that prevent indiscriminate activation of nearby genes. In the July 1, 2009, issue of Genes & Development, Chopra and colleagues (pp. 1505–1509) report that promoters containing a stalled Pol II are activated by enhancers, but these promoters also serve as insulators that block enhancers from reaching more distal genes. This new class of insulators provide critical clues to regulatory mechanisms.
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↵1 Corresponding author.
E-MAIL jtl10{at}cornell.edu; FAX (607) 255-2428.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1827709.
- Copyright © 2009 by Cold Spring Harbor Laboratory Press