Protein networks in disease

  1. Trey Ideker1 and
  2. Roded Sharan2,3
  1. 1 Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA;
  2. 2 School of Computer Science, Tel-Aviv University, Tel-Aviv 69978, Israel

Abstract

During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage.

Footnotes

  • 3 Corresponding author.

    3 E-mail roded{at}post.tau.ac.il; fax 972-3-6409357.

  • Article is online at http://www.genome.org/cgi/doi/10.1101/gr.071852.107.

  • Freely available online through the Genome Research Open Access option.

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