A second-generation combined linkage–physical map of the human genome
- Tara C. Matise1,10,
- Fang Chen1,
- Wenwei Chen2,
- Francisco M. De La Vega3,
- Mark Hansen4,
- Chunsheng He1,7,
- Fiona C.L. Hyland3,
- Giulia C. Kennedy2,
- Xiangyang Kong1,8,
- Sarah S. Murray4,9,
- Janet S. Ziegle3,
- William C.L. Stewart5, and
- Steven Buyske1,6
- 1 Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA;
- 2 Affymetrix, Inc., Santa Clara, California 95051, USA;
- 3 Applied Biosystems, Inc., Foster City, California 94404, USA;
- 4 Illumina, Inc., San Diego, California 92121, USA;
- 5 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48104, USA;
- 6 Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA
Abstract
We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific linkage map distances, along with confidence intervals, have been estimated for all map intervals. In addition, a regression-based smoothed map is provided that facilitates interpolation of positions of unmapped markers on this map. With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers.
Footnotes
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↵7 Present addresses: Laboratory of Statistical Genetics, Rockefeller University, New York, NY 10065, USA;
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↵8 Glaxo Smithkline, Research Triangle Park, NC 27709, USA;
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↵9 Scripps Genomic Medicine, La Jolla, CA 92037, USA.
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↵10 Corresponding author.
↵10 E-mail matise{at}biology.rutgers.edu; fax (732) 445-4972.
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Article published online before print. Article and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.7156307
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- Received September 28, 2007.
- Accepted October 11, 2007.
- Copyright © 2007, Cold Spring Harbor Laboratory Press