A second-generation combined linkage–physical map of the human genome

  1. Tara C. Matise1,10,
  2. Fang Chen1,
  3. Wenwei Chen2,
  4. Francisco M. De La Vega3,
  5. Mark Hansen4,
  6. Chunsheng He1,7,
  7. Fiona C.L. Hyland3,
  8. Giulia C. Kennedy2,
  9. Xiangyang Kong1,8,
  10. Sarah S. Murray4,9,
  11. Janet S. Ziegle3,
  12. William C.L. Stewart5, and
  13. Steven Buyske1,6
  1. 1 Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA;
  2. 2 Affymetrix, Inc., Santa Clara, California 95051, USA;
  3. 3 Applied Biosystems, Inc., Foster City, California 94404, USA;
  4. 4 Illumina, Inc., San Diego, California 92121, USA;
  5. 5 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48104, USA;
  6. 6 Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA

Abstract

We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific linkage map distances, along with confidence intervals, have been estimated for all map intervals. In addition, a regression-based smoothed map is provided that facilitates interpolation of positions of unmapped markers on this map. With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers.

Footnotes

  • 7 Present addresses: Laboratory of Statistical Genetics, Rockefeller University, New York, NY 10065, USA;

  • 8 Glaxo Smithkline, Research Triangle Park, NC 27709, USA;

  • 9 Scripps Genomic Medicine, La Jolla, CA 92037, USA.

  • 10 Corresponding author.

    10 E-mail matise{at}biology.rutgers.edu; fax (732) 445-4972.

  • Article published online before print. Article and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.7156307

    • Received September 28, 2007.
    • Accepted October 11, 2007.
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