ATM: Sounding the Double-strand Break Alarm

  1. Y. SHILOH
  1. Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

This extract was created in the absence of an abstract.

Excerpt

Structural alterations in the DNA, arising spontaneously or induced by damaging agents or normalmetabolites, are handled by a broad repertoire of repairmechanisms. Although research on DNA damage responses focused initially on the actual repair process, evidence is mounting of a parallel induction of a wide arrayof signaling pathways in response to DNA damage(Lowndes and Murguia 2000; Schmidt-Ullrich et al.2000). These pathways alert numerous cellular systems tothe presence of DNA damage and modulate their activityaccordingly. A well-documented example is the activation of cell cycle checkpoints by an elaborate network ofpathways that is still being uncovered (Dasika et al.1999). The vigorous wave of alterations in gene expression that follows DNA damage (Amundson et al. 1999;Jelinsky and Samson 1999; S. Rashi-Elkeles et al., inprep.) also indicates that the scope of cellular responses tosuch damage may be considerably wider than previouslyestimated...

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