Wavelength-modulated differential photothermal radiometry: Theory and experimental applications to glucose detection in water

Andreas Mandelis and Xinxin Guo
Phys. Rev. E 84, 041917 – Published 14 October 2011

Abstract

A differential photothermal radiometry method, wavelength-modulated differential photothermal radiometry (WM-DPTR), has been developed theoretically and experimentally for noninvasive, noncontact biological analyte detection, such as blood glucose monitoring. WM-DPTR features analyte specificity and sensitivity by combining laser excitation by two out-of-phase modulated beams at wavelengths near the peak and the base line of a prominent and isolated mid-IR analyte absorption band (here the carbon-oxygen-carbon bond in the pyran ring of the glucose molecule). A theoretical photothermal model of WM-DPTR signal generation and detection has been developed. Simulation results on water-glucose phantoms with the human blood range (0–300 mg/dl) glucose concentration demonstrated high sensitivity and resolution to meet wide clinical detection requirements. The model has also been validated by experimental data of the glucose-water system obtained using WM-DPTR.

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  • Received 30 March 2011

DOI:https://doi.org/10.1103/PhysRevE.84.041917

©2011 American Physical Society

Authors & Affiliations

Andreas Mandelis and Xinxin Guo*

  • Center for Advanced Diffusion-Wave Technologies, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada M5S 3G8

  • *guox@mie.utoronto.ca

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Vol. 84, Iss. 4 — October 2011

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