Abstract
A differential photothermal radiometry method, wavelength-modulated differential photothermal radiometry (WM-DPTR), has been developed theoretically and experimentally for noninvasive, noncontact biological analyte detection, such as blood glucose monitoring. WM-DPTR features analyte specificity and sensitivity by combining laser excitation by two out-of-phase modulated beams at wavelengths near the peak and the base line of a prominent and isolated mid-IR analyte absorption band (here the carbon-oxygen-carbon bond in the pyran ring of the glucose molecule). A theoretical photothermal model of WM-DPTR signal generation and detection has been developed. Simulation results on water-glucose phantoms with the human blood range (0–300 mg/dl) glucose concentration demonstrated high sensitivity and resolution to meet wide clinical detection requirements. The model has also been validated by experimental data of the glucose-water system obtained using WM-DPTR.
13 More- Received 30 March 2011
DOI:https://doi.org/10.1103/PhysRevE.84.041917
©2011 American Physical Society