The development of phenylalanine hydroxylase in rat liver; in vivo, and in vitro studies utilizing fetal hepatocyte cultures
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Metabolic and feeding behavior alterations provoked by prenatal exposure to aspartame
2015, AppetiteCitation Excerpt :In rodents, high levels of accumulated Phe may be converted into other metabolites (Gazit, Ben-Shlomo, Ben-Shachar, Karnieli, & Katz, 1998; Scriver, Kaufman, Eisensmith, & Woo, 1995) that could interfere with normal metabolism (Gazit, Ben-Abraham, Rudin, & Katz, 2003; Gazit et al., 1998). In rodents, phenylalanine hydroxylase activity is absent until the end of gestation (Tourian, Treiman, & Carr, 1972; Yeoh et al., 1988). It is improbable that the concentration of phenylalanine in the brains of offspring is as high as that found in hyperphenylalaninemia, but a small chronic alteration in neuronal glucose homeostasis during prenatal development could lead to permanent changes in this parameter.
Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain
2011, Journal of Biological ChemistryCitation Excerpt :The broader distribution of AADC than TH in the brain may explain the constant level of the protein during the developmental period we examined. Phenylalanine metabolism in fetuses depends on the maternal body but becomes independent after birth (24). Consistently, phenylalanine content in DPS-Pts−/− and Spr−/− mice were relatively low at P0 and increased significantly at P7 and P14 (supplemental Fig. 1).
Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration
2010, Molecular Genetics and MetabolismCitation Excerpt :In mammals, PAH is mainly found in the liver and kidney, and is also abundant in skin; epidermal PAH activities correlate linearly with skin phototypes where dark skin has the highest activities [3]. Hepatic PAH is short-term regulated by its substrate phenylalanine (positive allosteric effector) and BH4 levels (allosteric inhibitor) [4], some hormones [5,6], and by phosphorylation [7,8]. Some liver cells are relatively hypoxic compared to other somatic cells since they are located at the distal end of a portal system.
Developmental pattern of phenylalanine hydroxylase activity in the chicken
1999, Poultry ScienceDifferential effects of streptozotocin-induced diabetes on phenylalanine hydroxylase protein and mRNA abundance in isolated rat liver cells
1996, International Journal of Biochemistry and Cell Biology