The frequency-dependent ultrasound backscatter from tissues contains information about the microstructure that can be quantified. In many cases, the anatomic microstructure details responsible for ultrasonic scattering remain unidentified. However, their identification would lead to potentially improved methodologies for characterizing tissue and diagnosing disease from ultrasonic backscatter measurements. Recently, three-dimensional (3D) acoustic models of tissue microstructure, termed 3D impedance maps (3DZMs), were introduced to help to identify scattering sources [J. Mamou, M. L. Oelze, W. D. O’Brien, Jr., and J. F. Zachary, “Identifying ultrasonic scattering sites from 3D impedance maps,” J. Acoust. Soc. Am. 117, 413–423 (2005)]. In the current study, new 3DZM methodologies are used to model and identify scattering structures. New processing procedures (e.g., registration, interpolations) are presented that allow more accurate 3DZMs to be constructed from histology. New strategies are proposed to construct scattering models [i.e., form factor (FF)] from 3DZMs. These new methods are tested on simulated 3DZMs, and then used to evaluate 3DZMs from three different rodent tumor models. Simulation results demonstrate the ability of the extended strategies to accurately predict FFs and estimate scatterer properties. Using the 3DZM methods, distinct FFs and scatterer properties were obtained for each tumor examined.
REFERENCES
1.
M. F.
Insana
, R. F.
Wagner
, and D. G.
Brown
, “Describing small-scale structure in random media using pulse-echo ultrasound
,” J. Acoust. Soc. Am.
87
, 179
–192
(1990
).2.
E. J.
Feleppa
, F. L.
Lizzi
, D. J.
Coleman
, and M. M.
Yaremko
, “Diagnostics spectrum analysis ophthalmology: A physical perspective
,” Ultrasound Med. Biol.
12
, 623
–631
(1986
).3.
M. L.
Oelze
, J. F.
Zachary
, and W. D.
O’Brien
, Jr., “Characterization of tissue microstructure using ultrasonic backscatter: Theory and technique for optimization using a Gaussian form factor
,” J. Acoust. Soc. Am.
112
, 1202
–1211
(2002
).4.
M. L.
Oelze
, J. F.
Zachary
, and W. D.
O’Brien
, Jr., “Parametric imaging of rat mammary tumors in vivo for the purposes of tissue characterization
,” J. Ultrasound Med.
21
, 1201
–1210
(2002
).5.
M. L.
Oelze
, W. D.
O’Brien
, Jr., and J. F.
Zachary
, “Differentiation and characterization of rat mammary fibroadenomas and 4tl mouse carcinomas using quantitative ultrasound imaging
,” IEEE Trans. Med. Imaging
23
, 764
–771
(2004
).6.
M. L.
Oelze
and W. D.
O’Brien
, Jr., “Application of three scattering models to characterization of solid tumors in mice
,” Ultrason. Imaging
28
, 83
–96
(2006
).7.
D. J.
Coleman
, R. H.
Silverman
, M. J.
Rondeau
, H. C.
Boldt
, H. O.
Lloyd
, F. L.
Lizzi
, T. A.
Weingeist
, X.
Chen
, S.
Vangveeravong
, and R.
Folberg
, “Noninvasive in vivo detection of prognostic indicators for high-risk uveal melanoma: Ultrasound parameter imaging
,” Ophthalmology
111
, 558
–564
(2004
).8.
J. E.
Perez
, J. G.
Miller
, B.
Barzilai
, S.
Wickline
, G. A.
Mohr
, K.
Wear
, Z.
Vered
, and B. E.
Sobel
, “Quantitative characterization of myocardium with ultrasonic imaging
,” J. Nucl. Med. Allied Sci.
32
, 149
–157
(1988
).9.
F. L.
Lizzi
, M.
Greenebaum
, E. J.
Feleppa
, M.
Elbaum
, and D. J.
Coleman
, “Theoretical framework for spectrum analysis in ultrasonic tissue characterization
,” J. Acoust. Soc. Am.
73
, 1366
–1373
(1983
).10.
F. L.
Lizzi
, M.
Ostromogilsky
, E. J.
Feleppa
, M. C.
Rorke
, and M. M.
Yaremko
, “Relationship of ultrasonic spectral parameters to features of tissue microstructure
,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control
33
, 319
–329
(1986
).11.
M. F.
Insana
, J. G.
Wood
, and T. J.
Hall
, “Identifying acoustic scattering sources in normal renal parenchyma in vivo by varying arterial and ureteral pressures
,” Ultrasound Med. Biol.
17
, 613
–626
(1991
).12.
R. E.
Baddour
, M. D.
Sherar
, J. W.
Hunt
, G. J.
Czarnota
, and M. C.
Kolios
, “High-frequency ultrasound scattering from microspheres and single cells
,” J. Acoust. Soc. Am.
117
, 934
–943
(2005
).13.
M. C.
Kolios
, G. J.
Czarnota
, M.
Lee
, J. W.
Hunt
, and M. D.
Sherar
, “Ultrasonic spectral parameter characterization of apoptosis
,” Ultrasound Med. Biol.
28
, 589
–597
(2002
).14.
J.
Mamou
, M. L.
Oelze
, J. F.
Zachary
, and W. D.
O’Brien
, Jr., “Ultrasound scatterer size estimation technique based on a 3D acoustic impedance map from histologic sections
,” Proceedings of the 2003 IEEE Ultrasonics Symposium
, Honolulu, HI
, pp. 1022
–1025
(2003
).15.
J.
Mamou
, M. L.
Oelze
, W. D.
O’Brien
, Jr., and J. F.
Zachary
, “Identifying ultrasonic scattering sites from 3D impedance maps
,” J. Acoust. Soc. Am.
117
, 413
–423
(2005
).16.
J.
Mamou
, M. L.
Oelze
, W. D.
O’Brien
, Jr., and J. F.
Zachary
, “Ultrasound characterization of three animal mammary tumors from three-dimensional acoustic tissue models
,” Proceedings of the 2005 IEEE Ultrasonics Symposium
, Rotterdam, Netherlands
, pp. 866
–869
(2005
).17.
J.
Mamou
, M. L.
Oelze
, W. D
. O’Brien
, Jr., and J. F.
Zachary
, “A view on quantitative biomedical ultrasound imaging
,” IEEE Signal Process. Mag.
23
, 112
–116
(2006
).18.
19.
K. K.
Shung
and G. A.
Thieme
, Ultrasonic Scattering in Biological Tissues
(CRC
, Boca Raton, FL, 1993
).20.
V.
Caselles
, J.-L.
Lisani
, J.-M.
Morel
, and G.
Sapiro
, “Shape preserving local histogram modification
,” IEEE Trans. Image Process.
8
, 220
–230
(1999
).21.
J. P. W.
Pluim
, J. B. A.
Maintz
, and M. A.
Viergever
, “Mutual-information-based registration of medical images: A survey
,” IEEE Trans. Med. Imaging
22
, 986
–1004
(2003
).22.
J.
Kybic
and M.
Unser
, “Fast parametric elastic image registration
,” IEEE Trans. Image Process.
12
, 1427
–1442
(2003
).23.
J. V.
Hajnal
, D. L. G.
Hill
, and D. J.
Hawkes
, Medical Image Registration
(CRC
, Boca Raton, FL, 2001
).24.
G. P.
Penney
, J.
Weese
, J. A.
Little
, P.
Desmedt
, D. L. G.
Hill
, and D. J.
Hawkes
, “A comparison of similarity measures for use in 2-D-3-D medical image registration
,” IEEE Trans. Med. Imaging
17
, 586
–595
(1998
).25.
A. A.
Cole-Rhodes
, K. L.
Johnson
, J.
LeMoigne
, and I.
Zavorin
, “Multiresolution registration of remote sensing imagery by optimization of mutual information using a stochastic gradient
,” IEEE Trans. Image Process.
12
, 1495
–1511
(2003
).26.
C.
Studholme
, D. L. G.
Hill
, and D. J.
Hawkes
, “An overlap invariant entropy measure of 3D medical image alignment
,” Pattern Recogn.
32
, 71
–86
(1999
).27.
Y.-M.
Zhu
, “Volume image registration by cross-entropy optimization
,” IEEE Trans. Med. Imaging
21
, 174
–180
(2002
).28.
29.
F.
Maes
, D.
Vandermeulen
, and P.
Suetens
, “Comparative evaluation of multiresolution optimization strategies for multimodality image registration by maximization of mutual information
,” Med. Image Anal.
3
, 373
–386
(1999
).30.
M. J. D.
Powell
, “An efficient method for finding the minimum of a function of several variables without calculating derivatives
,” Comput. J.
7
, 155
–162
(1964
).31.
F.
Maes
, A.
Collignon
, D.
Vandermeulen
, G.
Marchal
, and P.
Suetens
, “Multimodality image registration by maximization of mutual information
,” IEEE Trans. Med. Imaging
16
, 187
–198
(1997
).32.
J. A.
Nelder
and R.
Mead
, “A simplex method for function minimization
,” Comput. J.
7
, 308
–313
(1965
).33.
N. A.
Dodgson
, “Quadratic interpolation for image resampling
,” IEEE Trans. Image Process.
6
, 1322
–1326
(1997
).34.
J.
Mamou
, “Ultrasonic characterization of three animal mammary tumors from three-dimensional acoustic tissue models
,” Ph.D. Dissertation: University of Illinois
at Urbana-Champaign (2005
).35.
T. A.
Bigelow
, M. L.
Oelze
, and W. D.
O’Brien
, Jr., “Estimation of total attenuation and scatterer size from backscattered ultrasound waveforms
,” J. Acoust. Soc. Am.
117
, 1
–10
(2005
).36.
M. L.
Oelze
and J. F.
Zachary
, “Examination of cancer in mouse models using quantitative ultrasound
,” Ultrasound Med. Biol.
32
, 1639
–1648
(2006
).37.
M. L.
Oelze
, W. D.
O’Brien
, Jr., and J. F.
Zachary
, “Quantitative ultrasound assessment of breast cancer using a multiparameter approach
,” Proceedings of the 2007 IEEE Ultrasonics Symposium
, New York City, NY
(2007
).© 2008 Acoustical Society of America.
2008
Acoustical Society of America
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