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Biochemical aspects of inflammation

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Abstract

This review considers biochemical aspects of inflammation. The international literature until December 2006 has been analyzed, with the principal attention paid to the most dynamic problems: enzymology of inflammation, its regulation by hormones and signal transducers, and negative feedbacks, which underlie intensive current studies on pathogenesis, diagnostics, and therapy of inflammation. Such achievements as discoveries of defensins, toll-like receptors, interconnections of inflammation and iron metabolism, the roles of oxidative stress and antioxidant defense, lipoxins, inflammatory components of “non-inflammatory” diseases, and action mechanisms of effective drugs are discussed.

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Abbreviations

EGF:

epidermal growth factor

FGF:

fibroblast growth factor

IL:

interleukins

NSAIDs:

nonsteroidal antiinflammatory drugs

PAF:

platelet-activating factor

PDGF:

platelet-derived growth factor

PG:

prostaglandins

PK:

protein kinases

TF:

transcriptional factor

TGF:

transforming growth factor

Th:

T-helpers

TK:

tyrosine kinases

TNF:

tumor necrosis factor

VEGF:

vascular endothelial growth factor

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  1. Department of Biochemistry, Irkutsk State Medical University, ul. Krasnogo Vosstaniya 1, 664003, Irkutsk, Russia

    V. I. Kulinsky

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Original Russian Text © V. I. Kulinsky, 2007, published in Biokhimiya, 2007, Vol. 72, No. 6, pp. 733–746.

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Kulinsky, V.I. Biochemical aspects of inflammation. Biochemistry Moscow 72, 595–607 (2007). https://doi.org/10.1134/S0006297907060028

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  • DOI: https://doi.org/10.1134/S0006297907060028

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