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Anti-inflammatory activity of polysaccharide from Pholiota nameko

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Abstract

Pholiota nameko polysaccharide (PNPS-1) has been isolated and purified by enzymatic hydrolysis, hot water extraction, ethanol precipitation, and ion-exchange and gel-filtration chromatography. The anti-inflammatory activity of PNPS-1 was evaluated in rodents using xylene-induced ear edema, egg albumin-, carrageenin-, and formaldehyde-induced paw edema, cotton pellet granuloma test, adhesion of peritoneal leukocytes in vitro, and ulcerogenic activity. The results showed that PNPS-1 (5 mg/ear) inhibited topical edema in the mouse ear and at 100, 200, and 400 mg/kg (intraperitoneally) it significantly suppressed the development of egg albumin-, carrageenin-, and formaldehyde-induced paw edema in the animals. PNPS-1 (100, 200, and 400 mg/kg, per oral) significantly inhibited the growth of granuloma tissues induced by subcutaneously implanted cotton pellets in rats by 10.96, 18.07, and 43.75%, respectively. PNPS-1 also inhibited spontaneous and phorbol-12-myristate-13-acetate-activated adhesion of peritoneal leukocytes in vitro. Further, both acute as well as chronic administration of PNPS-1 (100, 200, and 400 mg/kg, per oral) did not produce any gastric lesion in rats. In conclusion, these data indicated that PNPS-1 possesses significant anti-inflammatory activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory-related diseases.

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Abbreviations

ASA:

acetylsalicylic acid

C-PNPS:

crude P. nameko polysaccharide

PMA:

phorbol-12-myristate-13-acetate

PNPS-1:

Pholiota nameko polysaccharide

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Authors and Affiliations

  1. Tianjin Key Laboratory of Food Biotechnology, Faculty of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, 300134, P. R. China

    Haiping Li, Xiaoxiang Lu, Shuhai Zhang, Meijun Lu & Hongmei Liu

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  1. Haiping Li
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  2. Xiaoxiang Lu
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  3. Shuhai Zhang
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  4. Meijun Lu
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Correspondence to Haiping Li.

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Originally published in Biochemistry (Moscow) On-Line Papers in Press, as Manuscript BM07-375, March 30, 2008.

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Li, H., Lu, X., Zhang, S. et al. Anti-inflammatory activity of polysaccharide from Pholiota nameko . Biochemistry Moscow 73, 669–675 (2008). https://doi.org/10.1134/S0006297908060060

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