Abstract
Tissue activity of angiogenesis depends on the balance of many stimulating or inhibiting factors. The key signaling system that regulates proliferation and migration of endothelial cells forming the basis of any vessel are vascular endothelium growth factors (VEGF) and their receptors. The VEGF-dependent signaling system is necessary for formation of the embryonic vascular system. Neoangiogenesis during tumor growth is also associated with activation of this signaling system. The biological significance of the effect of such system on the cells depends on the content in tissue of various factors of the VEGF family and their receptors, while in the case of VEGFA it is defined by the ratio of different isoforms of this growth factor. A number of other signaling systems are also involved in regulation of the main steps of vessel formation. The signaling system D114/Notch regulates selection of endothelial cells for beginning of angiogenic expansion by endowing particular properties to endothelial cells leading in this process. An important step in vessel stabilization and maturation is vascular wall formation. Signaling system PDGFB/PDGFRß as well as angiopoietins Ang1, Ang2, and their receptor Tie2 are involved in recruiting mural cells (pericytes and smooth muscle cells). Identification of key molecules involved in the regulation of angiogenesis may provide new possibilities for development of drugs suitable for inhibition of angiogenesis or its stimulation in various pathologies.
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Abbreviations
- a.a.:
-
amino acid residues
- Ang:
-
angiopoietins
- EGF:
-
epidermal growth factor
- FGF:
-
fibroblast growth factor
- PDGF:
-
platelet-derived growth factor
- PlGF:
-
placental growth factor
- RTK:
-
receptor tyrosine kinases
- TGF:
-
transforming growth factor
- VEGF:
-
vascular endothelium growth factor
- VEGFR:
-
vascular endothelium growth factor receptor
References
Coultas, L., Chawengsaksophak, K., and Rossant, J. (2005) Nature, 438, 937–945.
Gerhardt, H., and Betsholtz, C. (2003) Cell Tissue Res., 314, 15–23.
Folkman, J. (1990) J. Natl. Cancer Inst., 82, 4.
Folkman, J. (1995) N. Engl. J. Med., 333, 1757–1763.
Ferrara, N., and Davis-Smyth, T. (1997) Endocr. Rev., 18, 4–25.
Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel, D. V., and Ferrara, N. (1989) Science, 246, 1306–1309.
Nagy, J. A., Vasile, E., Feng, D., Sundberg, C., Brown, L. F., Detmar, M. J., Lawitts, J. A., Benjamin, L., Tan, X., Manseau, E. J., Dvorak, A. M., and Dvorak, H. F. (2002) J. Exp. Med., 196, 1497–1506.
Gerber, H. P., Dixit, V., and Ferrara, N. (1998) J. Biol. Chem., 273, 13313–13316.
Gerber, H. P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V., and Ferrara, N. (1998) J. Biol. Chem., 273, 30366–30343.
Benjamin, L. E., Golijanin, D., Itin, A., Pode, D., and Keshet, E. (1999) J. Clin. Invest., 103, 159–165.
Gerber, H. P., Hillan, K. J., Ryan, A. M., Kowalski, J., Keller, G. A., Rangell, L., Wright, B. D., Radtke, F., Aguet, M., and Ferrara, N. (1999) Development, 126, 1149–1159.
Senger, D. R., Galli, S. J., Dvorak, A. M., Perruzzi, C. A., Harvey, V. S., and Dvorak, H. F. (1983) Science, 219, 983–985.
Dvorak, H. F., Brown, L. F., Detmar, L., and Dvorak, A. M. (1995) Am. J. Pathol., 146, 1029–1039.
Houck, K. A., Ferrara, N., Winer, J., Cachianes, G., Li, B., and Leung, D. W. (1991) Mol. Endocrinol., 5, 1806–1814.
Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., and Abraham, J. A. (1991) J. Biol. Chem., 266, 11947–11954.
Ferrara, N., and Henzel, W. J. (1989) Biochem. Biophys. Res. Commun., 161, 851–858.
Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., and Ferrara, N. (1992) J. Biol. Chem., 267, 26031–26037.
Park, J. E., Keller, H.-A., and Ferrara, N. (1993) Mol. Biol. Cell, 4, 1317–1326.
Keyt, B. A., Berleau, L. T., Nguyen, H. V., Chen, H., Heinsohn, H., Vandlen, R., and Ferrara, N. (1996) J. Biol. Chem., 271, 7788–7795.
Carmeliet, P., Ng, Y.-S., Nuyens, D., Theilmeier, G., Brusselmans, K., Cornelissen, I., Ehler, E., Kakkar, V. V., Stalmans, I., Mattot, V., Perriard, J.-C., Dewerchin, M., Flameng, W., Nagy, A., Lupu, F., Moons, L., Collen, D., D’Amore, P. A., and Shima, D. T. (1999) Nat. Med., 5, 495–502.
Dor, Y., Porat, R., and Keshet, E. (2001) Am. J. Physiol. Cell Physiol., 280, C1367–C1374.
Neufeld, G., Cohen, T., Gengrinovitch, S., and Poltorak, Z. (1999) FASEB J., 13, 9–22.
De Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. (1992) Science, 255, 989–991.
Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H., and Sato, M. (1990) Oncogene, 5, 519–524.
Terman, B. I., Carrion, M. E., Kovacs, E., Rasmussen, B. A., Eddy, R., and Shows, T. B. (1991) Oncogene, 6, 1677–1683.
Matthews, W., Jordan, C. T., Gavin, M., Jenkins, N. A., Copeland, N. G., and Lemischka, I. R. (1991) Proc. Natl. Acad. Sci. USA, 88, 9026–9030.
Millauer, B., Wizigmann-Voos, S., Schnurch, H., Martinez, R., Moller, N. P. H., Risau, W., and Ullrich, A. (1993) Cell, 72, 835–846.
Galland, F., Karamysheva, A., Pebusque, M. J., Borg, J. P., Rottapel, R., Dubreuil, P., Rosnet, O., and Birnbaum, D. (1993) Oncogene, 8, 1233–1240.
Pajusola, K., Aprelikova, O., Kohronen, J., Kaipainen, A., Petrovaara, L., Alitalo, R., and Alitalo, K. (1992) Cancer. Res., 52, 5738–5743.
Alitalo, K., and Carmeliet, P. (2002) Cancer Cell, 1, 219–227.
Sawano, A., Takahashi, T., Yamaguchi, S., Aonuma, M., and Shibuya, M. (1996) Cell Growth Differ., 7, 213–221.
Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D., Armaltno, D. C., Gospodarowicz, D., and Bohlen, P. (1992) Biochem. Biophys. Res. Commun., 187, 1579–1586.
Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C. H. (1994) J. Biol. Chem., 269, 26988–26995.
Seetharam, L., Gotoh, N., Maru, Y., Neufeld, G., Yamaguchi, S., and Shibuya, M. (1995) Oncogene, 10, 135–147.
Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., and Shibuya, M. (1998) Proc. Natl. Acad. Sci. USA, 95, 9349–9354.
Park, J. E., Chen, H. H., Winer, J., Houck, K. A., and Ferrara, N. (1994) J. Biol. Chem., 269, 25646–25654.
Kendall, R. L., and Thomas, K. A. (1993) Proc. Natl. Acad. Sci. USA, 90, 10705–10709.
Fong, G. H., Rossant, J., Gertsentein, M., and Breitman, M. L. (1995) Nature, 376, 66–70.
Stacker, S. A., Vitali, A., Caesar, C., Domagala, T., Groenen, L., Nice, E., Achen, M. A., and Wilks, A. F. (1999) J. Biol. Chem., 274, 34884–34892.
Olofsson, B., Korpelainen, E., Pepper, M. S., Mandriota, S. J., Aase, K., Kumar, V., Gunji, Y., Jeltsch, M. M., Shibuya, M., Alitalo, K., and Eriksson, U. (1998) Proc. Natl. Acad. Sci. USA, 95, 11709–11714.
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X. F., Breitman, M. L., and Schuh, A. C. (1995) Nature, 376, 62–66.
Eichmann, A., Corbel, C., Nataf, V., Vaigot, P., Breant, C., and le Douarin, N. M. (1997) Proc. Natl. Acad. Sci. USA, 94, 5141–5146.
Lyttle, D. J., Fraser, K. M., Fleming, S. B., Mercer, A. A., and Robinson, A. J. (1994) J. Virol., 68, 84–92.
Millauer, B., Shawver, L. K., Plate, K. H., Risau, W., and Ullrich, A. (1994) Nature, 367, 567–579.
Scobe, M., Rockwell, P., Goldstein, N., Vosseler, S., and Fusenig, N. E. (1997) Nat. Med., 3, 1222–1227.
Meyer, M., Clauss, M., Lepple-Wienhues, A., Waltenberger, J., Augustin, H. G., Ziche, M., Lanz, C., Buttner, M., Rziha, H. J., and Dehio, C. (1999) EMBO J., 18, 363–374.
Wise, L. M., Veikkola, T., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., Vitali, A., Makinen, T., Alitalo, K., and Stacker, S. A. (1999) Proc. Natl. Acad. Sci. USA, 96, 3071–3076.
Larcher, F., Murillas, R., Bolontrade, M., Conti, C. J., and Jorcano, J. L. (1998) Oncogene, 17, 303–311.
Shibuya, M. (2006) J. Biochem. Mol. Biol., 39, 469–478.
Jia, H., Bagherzadeh, A., Bicknell, R., Duchen, M. R., Liu, D., and Zachary, I. (2004) J. Biol. Chem., 279, 36148–36157.
Makinen, T., Veikkola, T., Mustjoki, S., Karpanen, T., Catimel, B., Nice, E. C., Wise, L., Mercer, A., Kowalski, H., Kerjaschki, D., Stacker, S. A., Achen, M. G., and Alitalo, K. (2001) EMBO J., 20, 4762–4773.
Lee, J., Gray, A., Yuan, J., Luoh, S.-M., Avraham, H., and Wood, W. I. (1996) Proc. Natl. Acad. Sci. USA, 93, 1988–1992.
Yamada, Y., Nezu, J., Shimane, M., and Hirata, Y. (1997) Genomics, 42, 483–488.
Achen, M. G., Jeltsch, M., Kukk, E., Makinen, T., Vitali, A., Wilks, A. F., Alitalo, K., and Stacker, S. A. (1998) Proc. Natl. Acad. Sci. USA, 95, 548–553.
Karkkainen, M. J., Haiko, P., Sainio K., Partanen, J., Taipale, J., Petrova, T. V., Jeltsch, M., Jackson, D. G., Talikka, M., Rauvala, H., Betsholtz, C., and Alitalo, K. (2004) Nature Immunol., 5, 74–80.
Baldwin, M. E., Halford, M. M., Roufail, S., Williams, R. A., Hibbs, M. L., Grail, D., Kubo, H., Stacker, S. A., and Achen, M. G. (2005) Mol. Cell. Biol., 25, 2441–2449.
Joukov, V., Sorsa, T., Kumar, V., Jeltsch, M., Claesson-Welsh, L., Cao, Y., Saksela, O., Kalkkinen, N., and Alitalo, K. (1997) EMBO J., 16, 3898–3911.
Stacker, S. A., Stenvers, K., Caesar, C., Vitali, A., Domagala, T., Nice, E., Roufail, S., Simpson, R. J., Moritz, R., Karpanen, T., Alitalo, K., and Achen, M. G. (1999) J. Biol. Chem., 274, 32127–32136.
Dixelius, J., Makinen, T., Wirzenius, M., Karkkainen, M. J., Wernstedt, C., Alitalo, K., and Claesson-Welsh, L. (2003) J. Biol. Chem., 278, 40973–40979.
Shushanov, S. S., Bronstein, M. I., Adelaide, J., Jussila, L., Tchipysheva, T., Jacquemier, J., Stavrovskaya, A., Birnbaum, D., and Karamysheva, A. (2000) Int. J. Cancer, 86, 47–52.
Soker, S., Takashima, S., Miao, H. Q., Neufeld, G., and Klagsbrun, M. (1998) Cell, 92, 735–745.
Klagsbrun, M., Takashima, S., and Mamluk, R. (2002) Adv. Exp. Med. Biol., 515, 33–48.
Neufeld, G., Cohen, T., Shraga, N., Lange, T., Kessler, O., and Herzog, Y. (2002) Trends Cardiovasc. Med., 12, 13–19.
Kawasaki, T., Kitsukawa, T., Bekku, Y., Matsuda, Y., Sanbo, M., Yagi, T., and Fujisawa, H. (1999) Development, 126, 4895–4902.
Yuan, L., Moyon, D., Pardanaud, L., Breant, C., Karkkainen, M. J., Alitalo, K., and Eichmann, A. (2002) Development, 129, 4797–4806.
Stalmans, I., Ng, Y.-S., Rohan, R., Fruttiger, M., Bouche, A., Yuce, A., Fujisawa, H., Hermans, B., Shani, M., Jansen, S., Hicklin, D., Anderson, D. J., Gardiner, T., Hammes, H.-P., Moons, L., Dewerchin, M., Collen, D., Carmeliet, P., and D’Amore, P. A. (2002) J. Clin. Invest., 109, 327–336.
Gu, C., Rodriguez, E. R., Reimert, D. V., Shu, T., Fritzsch, B., Richards, L. J., Kolodkin, A. L., and Ginty, D. D. (2003) Dev. Cell, 5, 45–57.
Karpanen, T., Heckman, C. A., Keskitalo, S., Jeltsch, M., Ollila, H., Neufeld, G., Tamagnone, L., and Alitalo, K. (2006) FASEB J., 20, 1462–1472.
Lee, S., Jilani, S. M., Nikolova, G. V., Carpizo, D., and Iruela-Arispe, M. L. (2005) J. Cell Biol., 169, 681–691.
Ladomery, M. R., Harper, S. J., and Bates, D. O. (2006) Cancer Lett., 249, 133–142.
Sainson, R. C., Aoto, J., Nakatsu, M. N., Holderfield, M., Conn, E., Koller, E., and Hughes, C. C. W. (2005) FASEB. J., 19, 1027–1029.
Uyttendaele, H., Ho, J., Rossant, J., and Kitajewski, J. (2001) Proc. Natl. Acad. Sci. USA, 98, 5643–5648.
Radtke, F., Schweisguth, F., and Pear, W. (2005) EMBO. Rep., 6, 1120–1125.
Le Borgne, R., Bardin, A., and Schweisguth, F. (2005) Development, 132, 1751–1762.
Fortini, M. E. (2002) Nat. Rev. Mol. Cell. Biol., 3, 673–684.
Shutter, J. R., Scully, S., Fan, W., Richards, W. G., Kitajewski, J., Deblandre, G. A., Kintner, C. R., and Stark, K. L. (2000) Genes Dev., 14, 1313–1318.
Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., Smith, G. H., Stark, K. L., and Gridley, T. (2000) Genes Dev., 14, 1343–1352.
Gale, N. W., Dominguez, M. G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D. M., Murphy, A. J., Adams, N. C., Lin, H. C., Holash, J., Thurston, G., and Yancopoulos, G. D. (2004) Proc. Natl. Acad. Sci. USA, 101, 15949–15954.
Benedito, R., and Duarte, A. (2005) Gene Exp. Patterns, 5, 750–755.
Duarte, A., Hirashima, M., Benedito, R., Trindade, A., Diniz, P., Bekman, E., Costa, L., Henrique, D., and Rossant, J. (2004) Genes Dev., 18, 2474–2478.
Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L., and Gridley, T. (2004) Genes Dev., 18, 2469–2473.
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., and Nagy, A. (1996) Nature, 380, 435–439.
Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’shea, K. S., Powell-Braxton, L., Hillan, K. J., and Moore, M. W. (1996) Nature, 380, 439–442.
Liu, Z., Shirakawa, T., Li, Y., Soma, A., Oka, M., Dotto, G. P., Fairman, R. M., Velazquez, O. C., and Herlyn, M. (2003) Mol. Cell. Biol., 23, 14–25.
Hellstrom, M., Phng L., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M. L., Kalen, M., Gerhardt, H., and Betsholtz, C. (2007) Nature, 445, 776–780.
Suchting, S., Freitas, C., Noble, F., Benedito, R., Breant, C., Duarte, A., and Eichmann, A. (2007) Proc. Natl. Acad. Sci. USA, 104, 3225–3230.
Siekmann, A. F., and Lawson, N. D. (2007) Nature, 445, 781–784.
Williams, C. K., Li, J., Murga, M., Harris, A. L., and Tosato, G. (2006) Blood, 107, 931–939.
Ridgway, J., Zhang, G., Wu, Y., Stawicki, S., Liang, W.-C., Chanthery, Y., Kowalski, J., Watts, R. J., Callahan, C., Kasman, I., Singh, M., Chien, M., Tan, C., Hongo, J.-A. S., Sauvage, F., Plowman, G., and Yan, M. (2006) Nature, 444, 1083–1087.
Noguera-Troise, I., Daly, C., Papadopoulos, N. J., Coetzee, S., Boland, P., Gale, N. W., Lin, H. C., Yancopoulos, G. D., and Thurston, G. (2006) Nature, 444, 1032–1037.
Lobov, I. B., Renard, R. A., Papadopoulos, N., Gale, N. W., Thurston, G., Yancopoulos, G. D., and Wiegand, S. J. (2007) Proc. Natl. Acad. Sci. USA, 104, 3219–3224.
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., and Betsholtz, C. J. (2003) Cell. Biol., 161, 1163–1177.
Jain, R. K. (2003) Nature Med., 9, 685–693.
Cleaver, O., and Melton, D. A. (2003) Nature Med., 9, 661–668.
Baluk, P., Hashizume, H., and McDonald, D. M. (2005) Curr. Opin. Genet. Dev., 15, 102–111.
Jain, R. K. (2005) Science, 307, 58–62.
Carmeliet, P., and Jain, R. K. (2000) Nature, 407, 249–257.
Ferrara, N., and Kerbel, R. S. (2005) Nature, 438, 967–974.
Betsholtz, C. (2004) Cytokine Growth Factor Rev., 15, 215–228.
Lindahl, P., Johansson, B. R., Leveen, P., and Betsholtz, C. (1997) Science, 277, 242–245.
Fredriksson, L., Li, H., and Eriksson, U. (2004) Cytokine. Growth Factor Rev., 15, 197–204.
Holmes, D. I., and Zachary, I. (2005) Genome Biol., 6, 209–219.
Kondo, K., Hiratuska, S., Subbalakshmi, E., Matsushime, H., and Shibuya, M. (1998) Gene, 208, 297–305.
Reigstad, L. J., Varhaug, J. E., and Lillehaug, J. R. (2005) FEBS J., 272, 5723–5741.
Bergers, G., and Song, S. (2005) Neurooncology, 7, 452–464.
Westermark, B., and Heldin, C. H. (1993) Acta Oncol., 32, 101–105.
Soriano, P. (1997) Development, 124, 2691–2700.
Hellstrom, M., Kalen, M., Lindahl, P., Abramsson, A., and Betsholtz, C. (1999) Development, 126, 3047–3055.
Hirschi, K. K., Rohovsky, S. A., Beck, L. H., Smith, S. R., and D’Amore, P. A. (1999) Circ. Res., 84, 298–305.
Armulik, A., Abramsson, A., and Betsholtz, C. (2005) Circ. Res., 97, 512–523.
Enge, M., Bjarnegard, M., Gerhardt, H., Gustafsson, E., Kalen, M., Asker, N., Hammes, H. P., Shani, M., Fassler, R., and Betsholtz, C. (2002) EMBO J., 21, 4307–4316.
Hirschi, K. K., Rohovsky, S. A., and D’Amore, P. A. (1998) J. Cell Biol., 141, 805–814.
Sims, D. E. (2000) Clin. Exp. Pharmacol. Physiol., 27, 842–846.
Orlidge, A., and D’Amore, P. A. (1987) J. Cell. Biol., 105, 1455–1462.
Sato, Y., and Rifkin, D. B. (1989) J. Cell. Biol., 109, 309–315.
Mandriota, S. J., Menoud, P. A., and Pepper, M. S. (1996) J. Biol. Chem., 271, 11500–11505.
Ramsauer, M., and D’Amore, P. A. (2002) J. Clin. Invest., 110, 1615–1617.
Ward, N. L., and Dumont, D. J. (2002) Semin. Cell Dev. Biol., 13, 19–27.
Thurston, G. (2003) Cell Tissue Res., 314, 61–68.
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S., Sato, T. N., and Yancopoulos, G. D. (1996) Cell, 87, 1171–1180.
Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg, B. K., Fujiwara, Y., Gendron, M. M., Gridley, T., Wolburg, H., Risau, W., and Qin, Y. (1995) Nature, 376, 70–74.
Dumont, D. J., Gradwohl, G., Fong, G.-H., Puri, M. C., Gerstenstein, M., Auerbach, A., and Breitman, M. L. (1994) Genes Dev., 8, 1897–1909.
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., Daly, T. J., Davis, S., Sato, T. N., and Yancopoulos, G. D. (1997) Science, 277, 55–60.
Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., and Yancopoulos, G. D. (1996) Cell, 87, 1161–1169.
Witzenbichler, B., Maisonpierre, P. C., Jones, P., Yancopoulos, G. D., and Isner, J. M. (1998) J. Biol. Chem., 273, 18514–18521.
Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., and Yancopoulos, G. D. (1998) Science, 282, 468–471.
Eklund, L., and Olsen, B. R. (2006) Exp. Cell Res., 312, 630–641.
Holash, J., Wiegand, S. J., and Yancopoulos, G. D. (1999) Oncogene, 18, 5356–5362.
Holash, J., Maisonpierre, P. C., Compton, D., Boland, P., Alexander, C. R., Zagzag, D., Yancopoulos, G. D., and Wiegand, S. J. (1999) Science, 284, 1994–1998.
Stratmann, A., Risau, W., and Plate, K. H. (1998) Am. J. Pathol., 153, 1459–1466.
Carmeliet, P. (2005) Nature, 438, 932–936.
Casanovas, O., Hicklin, D. J., Bergers, G., and Hanahan, D. (2005) Cancer Cell., 8, 299–309.
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Original Russian Text © A. F. Karamysheva, 2008, published in Biokhimiya, 2008, Vol. 73, No. 7, pp. 935–948.
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Karamysheva, A.F. Mechanisms of angiogenesis. Biochemistry Moscow 73, 751–762 (2008). https://doi.org/10.1134/S0006297908070031
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DOI: https://doi.org/10.1134/S0006297908070031