Abstract
Silicon nanocrystals dispersed in water have been used to photosensitize the generation of active oxygen. The photosensitizing efficiency has been estimated through the quenching of the exciton photoluminescence of silicon nanocrystals. Experiments have revealed a strong (up to 80%) decrease in the number of cancer mouse fibroblast cells when they come into contact with photoexcited silicon nanocrystals. The obtained results show that the use of silicon nanocrystals for biomedical applications, in particular, for photodynamic therapy of cancer, is feasible.
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References
Semiconductor Nanocrystals: From Basic Principles to Applications, Ed. by Al. Efros, D. J. Lockwood, and L. Tsybeskov (Kluwer Academic/Plenum, New York, 2004).
O. Bisi, S. Ossicini, and L. Pavesi, Surf. Sci. Rep. 38, 1 (2000).
P. K. Kashkarov, M. G. Lisachenko, O. A. Shalygina, et al., Zh. Éksp. Teor. Fiz. 124, 1255 (2003) [JETP 97, 1123 (2003)].
P. K. Kashkarov, L. A. Golovan, A. B. Fedotov, et al., J. Opt. Soc. Am. B 19, 2273 (2002).
D. Kovalev, V. Yu. Timoshenko, E. Gross, et al., Phys. Rev. Lett. 87, 068301 (2001).
D. Kovalev, E. Gross, N. Künzner, et al., Phys. Rev. Lett. 89, 137401 (2002).
E. Gross, D. Kovalev, N. Künzner, et al., Phys. Rev. B 68, 115405 (2003).
N. J. Turro, Modern Molecular Photochemistry (Univ. Sci., Sausalito, CA, 1991).
Photodynamic Tumor Therapy: 2nd and 3rd Generation Photosensitizers, Ed. by J. G. Moser (Harwood Academic, Amsterdam, 1998).
D. Kovalev, E. Gross, J. Diener, et al., Appl. Phys. Lett. 85, 3590 (2004).
M. Fujii, M. Usui, S. Hayashi, et al., J. Appl. Phys. 95, 3689 (2004).
M. Fujii, Sh. Minobe, M. Usui, et al., Phys. Rev. B 70, 085311 (2004).
W. Kueng, E. Silber, and U. Eppenberger, Anal. Biochem. 182, 16 (1989).
O. E. Grichenko, V. V. Shaposhnikova, A. A. Kudryavtsev, and Yu. N. Korystov, Izv. Ross. Akad. Nauk, Ser. Biol., No. 3, 274 (2004).
H. Steller, Science 267, 1445 (1995).
D. Kovalev, H. Heckler, G. Polisski, and F. Koch, Phys. Status Solidi B 215, 871 (1999).
M. Fujii, D. Kovalev, Sh. Minobe, et al., Phys. Rev. B 72, 165321 (2005).
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Original Russian Text © V.Yu. Timoshenko, A.A. Kudryavtsev, L.A. Osminkina, A.S. Vorontsov, Yu.V. Ryabchikov, I.A. Belogorokhov, D. Kovalev, P.K. Kashkarov, 2006, published in Pis’ma v Zhurnal Éksperimental’noĭ i Teoreticheskoĭ Fiziki, 2006, Vol. 83, No. 9, pp. 492–495.
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Timoshenko, V.Y., Kudryavtsev, A.A., Osminkina, L.A. et al. Silicon nanocrystals as photosensitizers of active oxygen for biomedical applications. Jetp Lett. 83, 423–426 (2006). https://doi.org/10.1134/S0021364006090128
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DOI: https://doi.org/10.1134/S0021364006090128