North of England evidence based guidelines development project: methods of developing guidelines for efficient drug use in primary care

Practice guidelines are valid if “they lead to the health gains and costs predicted for them.”1 When implemented, valid guidelines lead to changes in clinical practice and improvements in outcomes for patients.2-5 Invalid guidelines, however, may lead to the use of ineffective interventions that waste resources, or even to harm.

Guidelines must offer recommendations for both effective and efficient care, and these have not previously been available in the United Kingdom. We have reported the development and content of guidelines for primary care in the United Kingdom based explicitly on evidence of effectiveness.6-9 Here, we present the methods used to develop evidence based guidelines on the use in primary care of four important groups of drugs—angiotensin converting enzyme inhibitors in patients with heart failure, choice of antidepressants, non-steroidal anti-inflammatory drugs in patients with osteoarthritis, and aspirin as an antithrombotic agent.10-13 Abridged versions of the guidelines on angiotensin converting enzyme inhibitors, aspirin, and non-steroidal anti-inflammatory drugs will be published in subsequent articles.14-16