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Imaging
Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans
  1. C Feinlea,
  2. P Kunzb,
  3. P Boesigerb,
  4. M Frieda,
  5. W Schwizera
  1. aDepartment of Internal Medicine, Division of Gastroenterology, University Hospital Zürich, Switzerland, bInstitute of Biomedical Engineering and Medical Informatics, University/ETH Zürich, Switzerland
  1. Dr C Feinle, Department of Internal Medicine, Division of Gastroenterology, University Hospital Zürich, Rämistr. 100, 8091 Zürich, Switzerland.

Abstract

Background We have previously used a magnetic resonance imaging (MRI) method to study gastric emptying of liquids. So far, however, it has not possible to assess solid gastric emptying with this technique.

Aims To validate scintigraphically MRI as a method for measuring emptying of a mixed solid/liquid meal.

Methods In eight healthy subjects, gastric emptying of a solid/liquid (SM) and a liquid meal (LM) of identical energy content and macronutrient composition was studied by scintigraphy and MRI for 120 minutes.

Results MRI and scintigraphy agreed with respect to emptying profiles (intraclass correlation coefficient (RI) SM: 0.988, RI, LM: 0.917), t1/2 (SMMRI: 129 (9), SMScinti: 123 (11) minutes, NS; LMMRI: 100 (7), LMScinti: 110 (8) minutes, NS) and AUC (SMMRI: 8999 (232), SMScinti: 8788 (277) min%, NS; LMMRI: 8819 (368), LMScinti: 8891 (321) min%, NS).

Conclusions MRI can be used to measure reliably gastric emptying not only of liquid but also of mixed solid/liquid meals in humans.

  • magnetic resonance imaging
  • scintigraphy
  • gastric emptying
  • solid meal
  • liquid meal

  • Abbreviations

    MRI
    magnetic resonance imaging
    Gd-DOTA
    gadolinium tetraazacyclododecane tetraacetic acid
    AUC
    area under the curve
    RI
    intraclass correlation coefficient

    • https://doi.org/10.1136/gut.44.1.106

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    • Abbreviations

      MRI
      magnetic resonance imaging
      Gd-DOTA
      gadolinium tetraazacyclododecane tetraacetic acid
      AUC
      area under the curve
      RI
      intraclass correlation coefficient
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