You are here

Article Text

Article menu

Download PDFPDF

Review series
α1-Antitrypsin deficiency • 4: Molecular pathophysiology
Free

Abstract

The molecular basis of α1-antitrypsin deficiency is reviewed and is shown to be due to the accumulation of mutant protein as ordered polymers within the endoplasmic reticulum of hepatocytes. The current goals are to determine the cellular response to polymeric α1-antitrypsin and to develop therapeutic strategies to block polymerisation in vivo.

  • α1-antitrypsin deficiency
  • molecular pathophysiology

https://doi.org/10.1136/thx.2003.006528

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.