1932

Abstract

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among phospholipids in that its head group can be phosphorylated at multiple free hydroxyls. Several phosphorylated derivatives of phosphatidylinositol, collectively termed phosphoinositides, have been identified in eukaryotic cells from yeast to mammals. Phosphoinositides are involved in the regulation of diverse cellular processes, including proliferation, survival, cytoskeletal organization, vesicle trafficking, glucose transport, and platelet function. The enzymes that phosphorylate phosphatidylinositol and its derivatives are termed phosphoinositide kinases. Recent advances have challenged previous hypotheses about the substrate selectivity of different phosphoinositide kinase families. Here we re-examine the pathways of phosphoinositide synthesis and the enzymes involved.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.67.1.481
1998-07-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/biochem/67/1/annurev.biochem.67.1.481.html?itemId=/content/journals/10.1146/annurev.biochem.67.1.481&mimeType=html&fmt=ahah

Literature Cited

  1. Divecha N, Irvine RF. 1995. Cell 80:269–78
  2. Rittenhouse SE. 1996. Blood 88:4401–14
  3. Toker A, Cantley LC. 1997. Nature 387:673–76
  4. Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD. 1997. Trends Biochem. Sci. 22:267–72
  5. Zvelebil MJ, MacDougall L, Leevers S, Volinia S, Vanhaesebroeck B. et al. 1996. Philos. Trans. R. Soc. London Ser. B 351:217–23
  6. Loijens JC, Boronenkov IV, Parker GJ, Anderson RA. 1996. Adv. Enzyme Regul. 36:115–40
  7. Domin J, Waterfield MD. 1997. FEBS Lett. 410:91–95
  8. Duckworth BC, Cantley LC. 1996. In Handbook of Lipid Research: Lipid Second Messengers, ed. RM Bell, JH Exton 8125–75 New York: Plenum
  9. Franke TF, Kaplan DR, Cantley LC. 1997. Cell 88:435–37
  10. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A. et al. 1991. Cell 64:281–302
  11. Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A. et al. 1997. Science 276:1848–50
  12. Morris JZ, Tissenbaum HA, Ruvkun G. 1996. Nature 382:536–39
  13. Hiles ID, Otsu M, Volinia S, Fry MJ, Gout I. et al. 1992. Cell 70:419–29
  14. Hu P, Mondino A, Skolnik EY, Schlessinger J. 1993. Mol. Cell. Biol. 13:7677–88
  15. Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH. et al. 1997. Proc. Natl. Acad. Sci. USA 94:4330–35
  16. Leevers SJ, Weinkove D, MacDougall LK, Hafen E, Waterfield MD. 1996. EMBO J. 15:6584–94
  17. Zhou K, Takegawa K, Emr SD, Firtel RA. 1995. Mol. Cell. Biol. 15:5645–56
  18. Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS. et al. 1990. J. Biol. Chem. 265:19704–11
  19. Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA. et al. 1991. Cell 65:75–82
  20. Otsu M, Hiles I, Gout I, Fry MJ, Ruiz-Larrea F. et al. 1991. Cell 65:91–104
  21. Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R. et al. 1991. Cell 65:83–90
  22. Fruman DA, Cantley LC, Carpenter CL. 1996. Genomics 37:113–21
  23. Antonetti DA, Algenstaedt P, Kahn CR. 1996. Mol. Cell. Biol. 16:2195–203
  24. Inukai K, Anai M, Van Breda E, Hosaka T, Katagiri H. et al. 1996. J. Biol. Chem. 271:5317–20
  25. Inukai K, Funaki M, Ogihara T, Katagiri H, Kanda A. et al. 1997. J. Biol. Chem. 272:7873–82
  26. Pons S, Asano T, Glasheen E, Miralpeix M, Zhang YT. et al. 1995. Mol. Cell. Biol. 15:4453–65
  27. Reif K, Gout I, Waterfield MD, Cantrell DA. 1993. J. Biol. Chem. 268:10780–88
  28. Baltensperger K, Kozma LM, Jaspers SR, Czech MP. 1994. J. Biol. Chem. 269:28937–46
  29. Shepherd PR, Nave BT, Rincon J, Nolte LA, Bevan AP. et al. 1997. J. Biol. Chem. 272:19000–7
  30. Weinkove D, Leevers SJ, MacDougall LK, Waterfield MD. 1997. J. Biol. Chem. 272:14606–10
  31. Stephens L, Smrcka A, Cooke FT, Jackson TR, Sternweis PC. et al. 1994. Cell 77:83–93
  32. Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M. et al. 1995. Science 269:690–93
  33. Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F. et al. 1997. Cell 89:105–14
  34. Rameh LE, Tolias KF, Duckworth BC, Cantley LC. 1997. Nature 390:192–96
  35. Stephens LR, Hughes KT, Irvine RF. 1991. Nature 351:33–39
  36. End P, Gout I, Fry MJ, Panayotou G, Dhand R. et al. 1993. J. Biol. Chem. 268:10066–75
  37. Carpenter CL, Auger KR, Duckworth BC, Hou WM, Schaffhausen B. et al. 1993. Mol. Cell. Biol. 13:1657–65
  38. Dhand R, Hiles I, Panayotou G, Roche S, Fry MJ. et al. 1994. EMBO J. 13:522–33
  39. Stoyanova S, Bulgarelli-Leva G, Kirsch C, Hanck T, Klinger R. et al. 1997. Biochem. J. 324:489–95
  40. Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL. 1994. J. Biol. Chem. 269:20648–52
  41. Freund GG, Wittig JG, Mooney RA. 1995. Biochem. Biophys. Res. Commun. 206:272–78
  42. Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B. et al. 1996. Mol. Cell. Biol. 16:1722–33
  43. Vlahos CJ, Matter WF, Hui KY, Brown RF. 1994. J. Biol. Chem. 269:5241–48
  44. Meyers R, Cantley LC. 1997. J. Biol. Chem. 272:4384–90
  45. Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC Jr, Abraham RT. 1996. EMBO J. 15:5256–67
  46. Hartley KO, Gell D, Smith GCM, Zhang H, Divecha N. et al. 1995. Cell 82:849–56
  47. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I. et al. 1994. Nature 370:527–32
  48. Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. 1996. EMBO J. 15:2442–51
  49. Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D. et al. 1997. Cell 89:457–67
  50. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J. 1997. EMBO J. 16:2783–93
  51. Zhou SY, Shoelson SE, Chaudhuri M, Gish G, Pawson T. et al. 1993. Cell 72:767–78
  52. Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC. 1996. Nat. Struct. Biol. 3:364–74
  53. Booker GW, Breeze AL, Downing AK, Panayotou G, Gout I. et al. 1992. Nature 358:684–87
  54. Backer JM, Myers MJ, Shoelson SE, Chin DJ, Sun XJ. et al. 1992. EMBO J. 11:3469–79
  55. Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B. et al. 1993. J. Biol. Chem. 268:9478–83
  56. Druker BJ, Ling LE, Cohen B, Roberts TM, Schaffhausen BS. 1990. J. Virol. 64:4454–61
  57. Ling LE, Druker BJ, Cantley LC, Roberts TM. 1992. J. Virol. 66:1702–8
  58. Rameh LE, Chen C-S, Cantley LC. 1995. Cell 83:1–20
  59. Sparks AB, Rider JE, Hoffman NG, Fowlkes DM, Quilliam LA. et al. 1996. Proc. Natl. Acad. Sci. USA 93:1540–44
  60. Feng SB, Chen JK, Yu HT, Simon JA, Schreiber SL. 1994. Science 266:1241–47
  61. Booker GW, Gout I, Downing AK, Driscoll PC, Boyd J. et al. 1993. Cell 73:813–22
  62. Yu HT, Chen JK, Feng SB, Dalgarno DC, Brauer AW. et al. 1994. Cell 76:933–45
  63. Kapeller R, Prasad KVS, Janssen O, Hou W, Schaffhausen BS. et al. 1994. J. Biol. Chem. 269:1927–33
  64. Liu XQ, Marengere LE, Koch CA, Pawson T. 1993. Mol. Cell. Biol. 13:5225–32
  65. Vogel LB, Fujita DJ. 1993. Mol. Cell. Biol. 13:7408–17
  66. Prasad KVS, Janssen O, Kapeller R, Raab M, Cantley LC. et al. 1993. Proc. Natl. Acad. Sci. USA 90:7366–70
  67. Prasad KVS, Kapeller R, Janssen O, Duke-Cohan JS, Repke H. et al. 1993. Philos. Trans. R. Soc. London Ser. 342:35–42
  68. Karnitz LM, Sutor SL, Abraham RT. 1994. J. Exp. Med. 179:1799–808
  69. Pleiman CM, Hertz WM, Cambier JC. 1994. Science 263:1609–12
  70. Xu WQ, Harrison SC, Eck MJ. 1997. Nature 385:595–602
  71. Sicheri F, Moarefi I, Kuriyan J. 1997. Nature 385:602–9
  72. Soltoff SP, Cantley LC. 1996. J. Biol. Chem. 271:563–67
  73. Musacchio A, Cantley LC, Harrison SC. 1996. Proc. Natl. Acad. Sci. USA 93:14373–78
  74. Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB. et al. 1997. Nature 385:458–61
  75. Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D. et al. 1997. Nature 388:693–97
  76. Zheng Y, Bagrodia S, Cerione RA. 1994. J. Biol. Chem. 269:18727–30
  77. Tolias KF, Cantley LC, Carpenter CL. 1995. J. Biol. Chem. 270:17656–59
  78. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. 1997. Science 275:394–97
  79. Tang XW, Downes CP. 1997. J. Biol. Chem. 272:14193–99
  80. Okada T, Hazeki O, Ui M, Katada T. 1996. Biochem. J. 317:475–80
  81. Rubio I, Rodriguez-Viciana P, Downward J, Wetzker R. 1997. Biochem. J. 326:891–5
  82. MacDougall LK, Domin J, Waterfield MD. 1995. Curr. Biol. 5:1404–15
  83. Molz L, Chen Y-W, Hirano M, Williams LT. 1996. J. Biol. Chem. 271:13892–99
  84. Virbasius JV, Guilherme A, Czech MP. 1996. J. Biol. Chem. 271:13304–7
  85. Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ. et al. 1997. Biochem. J. 326:139–47
  86. Herman PK, Emr SD. 1990. Mol. Cell. Biol. 10:6742–54
  87. Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD. et al. 1993. Science 260:88–91
  88. Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R. et al. 1995. EMBO J. 14:3339–48
  89. Linassier C, MacDougall LK, Domin J, Waterfield MD. 1997. Biochem. J. 321:849–56
  90. Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B. et al. 1995. J. Biol. Chem. 270:11358–66
  91. Toker A, Bachelot C, Chen C-S, Falck JR, Hartwig JH. et al. 1995. J. Biol. Chem. 270:29525–31
  92. Stack JH, Herman PK, Schu PV, Emr SD. 1993. EMBO J. 12:2195–204
  93. Panaretou C, Domin J, Cockcroft S, Waterfield MD. 1997. J. Biol. Chem. 272:2477–85
  94. Pike LJ. 1992. Endocr. Rev. 13:692–706
  95. Whitman M, Kaplan D, Roberts T, Cantley L. 1987. Biochem. J. 247:165–74
  96. Endemann G, Dunn SN, Cantley LC. 1987. Biochemistry 26:6845–52
  97. Walker DH, Dougherty N, Pike LJ. 1988. Biochemistry 27:6504–11
  98. Graziani A, Ling LE, Endemann G, Carpenter CL, Cantley LC. 1992. Biochem. J. 284:39–45
  99. Ling LE, Schulz JT, Cantley LC. 1989. J. Biol. Chem. 264:5080–88
  100. Endemann GC, Graziani A, Cantley LC. 1991. Biochem. J. 273:63–66
  101. Thompson DM, Cochet C, Chambaz EM, Gill GN. 1985. J. Biol. Chem. 260:8824–30
  102. Wiedemann C, Schafer T, Burger MM. 1996. EMBO J. 15:2094–101
  103. Prasad KVS, Kapeller R, Janssen O, Repke H, Duke-Cohan JS. et al. 1993. Mol. Cell. Biol. 13:7708–17
  104. Berditchevski F, Tolias KF, Wong K, Carpenter CL, Hemler ME. 1997. J. Biol. Chem. 272:2595–98
  105. Li YS, Porter FD, Hoffman RM, Deuel TF. 1989. Biochem. Biophys. Res. Commun. 160:202–9
  106. Yoshida S, Ikeda E, Uno I, Mitsuzawa H. 1992. Mol. Gen. Genet. 231:337–44
  107. Yoshida S, Ohya Y, Goebl M, Nakano A, Anraku Y. 1994. J. Biol. Chem. 269:1166–72
  108. Yoshida S, Ohya Y, Nakano A, Anraku Y. 1994. Mol. Gen. Genet. 242:631–40
  109. Wong K, Cantley LC. 1994. J. Biol. Chem. 269:28878–84
  110. Nakagawa T, Goto K, Kondo H. 1996. Biochem. J. 320:643–49
  111. Gehrmann T, Vereb G, Schmidt M, Klix D, Meyer HE. et al. 1996. Biochim. Biophys. Acta 1311:53–63
  112. Nakagawa T, Goto K, Kondo H. 1996. J. Biol. Chem. 271:12088–94
  113. Wong K, Meyers R, Cantley LC. 1997. J. Biol. Chem. 272:13236–41
  114. Cutler NS, Heitman J, Cardenas ME. 1997. J. Biol. Chem. 272:27671–77
  115. Flanagan CA, Schnieders EA, Emerick AW, Kunisawa R, Admon A. et al. 1993. Science 262:1444–48
  116. Garcia BJ, Marini F, Stevenson I, Frei C, Hall MN. 1994. EMBO J. 13:2352–61
  117. Balla T, Downing GJ, Jaffe H, Kim S, Zolyomi A. et al. 1997. J. Biol. Chem. 272:18358–66
  118. Flanagan CA, Thorner J. 1992. J. Biol. Chem. 267:24117–25
  119. Nakanishi S, Catt KJ, Balla T. 1995. Proc. Natl. Acad. Sci. USA 92:5317–21
  120. Downing GJ, Kim S, Nakanishi S, Catt KJ, Balla T. 1996. Biochemistry 35:3587–94
  121. Hippen KL, Buhl AM, D'Ambrosio D, Nakamura K, Persin C. et al. 1997. Immunity 7:49–58
  122. Keith CT, Schreiber SL. 1995. Science 270:50–51
  123. Carr AM. 1996. Science 271:314–15
  124. Hoekstra MF. 1997. Curr. Opin. Genet. Dev. 7:170–75
  125. Brown EJ, Beal PA, Keith CT, Chen J, Shin TB. et al. 1995. Nature 377:441–46
  126. Jung M, Kondratyev A, Lee SA, Dimtchev A, Dritschilo A. 1997. Cancer Res. 57:24–27
  127. Sabatini DM, Pierchala BA, Barrow RK, Schell MJ, Snyder SH. 1995. J. Biol. Chem. 270:20875–78
  128. Cardenas ME, Heitman J. 1995. EMBO J. 14:5892–907
  129. Zheng XF, Fiorentino D, Chen J, Crabtree GR, Schreiber SL. 1995. Cell 82:121–30
  130. Boronenkov IV, Anderson RA. 1995. J. Biol. Chem. 270:2881–84
  131. Ishihara H, Shibasaki Y, Kizuki N, Katagiri H, Yazaki Y. et al. 1996. J. Biol. Chem. 271:23611–14
  132. Loijens JC, Anderson RA. 1996. J. Biol. Chem. 271:32937–43
  133. Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV. 1997. J. Biol. Chem. 272:5861–70
  134. Zhang X, Loijens JC, Boronenkov IV, Parker GJ, Norris FA. et al. 1997. J. Biol. Chem. 272:17756–61
  135. Yamamoto A, DeWald DB, Boronenkov IV, Anderson RA, Emr SD. et al. 1995. Mol. Biol. Cell 6:525–39
  136. Moritz A, De Graan PNE, Gispen WH, Wirtz KWA. 1992. J. Biol. Chem. 267:7207–10
  137. Jenkins GH, Fisette PL, Anderson RA. 1994. J. Biol. Chem. 269:11547–54
  138. Whiteford CC, Brearley CA, Ulug ET. 1997. Biochem. J. 323:597–601
  139. Dove SK, Cooke FT, Douglas MR, Sayers LG, Parker PJ, Michell RH. 1997. Nature 390:187–92
  140. Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. 1994. Cell 79:507–13
  141. Tolias KF, Couvillon AD, Cantley LC, Carpenter CL. 1998. Mol. Cell. Biol. 18:762–70
  142. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA. et al. 1995. Cell 82:1–20
  143. Zigmond SH, Joyce M, Borleis J, Bokoch GM, Devreotes PN. 1997. J. Cell Biol. 138:363–74
  144. Urumow T, Wieland OH. 1988. Biochim. Biophys. Acta 972:232–38
  145. Bazenet CE, Ruano AR, Brockman JL, Anderson RA. 1990. J. Biol. Chem. 265:18012–22
  146. Divecha N, Truong O, Hsuan JJ, Hinchliffe KA, Irvine RF. 1995. Biochem. J. 309:715–19
  147. Yamamoto K, Graziani A, Carpenter C, Cantley LC, Lapetina EG. 1990. J. Biol. Chem. 265:22086–89
  148. Banfic H, Tang X, Batty IH, Downes CP, Chen C, Rittenhouse SE. 1998. J. Biol. Chem. 273:13–16
  149. Carpenter CL, Cantley LC. 1990. Biochemistry 29:11147–56
  150. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC. 1989. Cell 57:167–75
  151. Cunningham TW, Lips DL, Bansal VS, Caldwell KK, Mitchell CA. et al. 1990. J. Biol. Chem. 265:21676–83
  152. Cunningham TW, Majerus PW. 1991. Biochem. Biophys. Res. Commun. 175:568–76
  153. Hawkins PT, Jackson TR, Stephens LR. 1992. Nature 358:157–59
  154. Carter AN, Huang RS, Sorisky A, Downes CP, Rittenhouse SE. 1994. Biochem. J. 301:415–20
  155. Berridge MJ. 1987. Annu. Rev. Biochem. 56:159–93
  156. Serunian LA, Haber MT, Fukui T, Kim JW, Rhee SG. et al. 1989. J. Biol. Chem. 264:17809–15
/content/journals/10.1146/annurev.biochem.67.1.481
Loading
/content/journals/10.1146/annurev.biochem.67.1.481
Loading

Data & Media loading...

  • Article Type: Introduction
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error