1932

Abstract

Abstract

The lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane of most gram-negative bacteria. lipid A is synthesized on the cytoplasmic surface of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. Diverse covalent modifications of the lipid A moiety may occur during its transit from the outer surface of the inner membrane to the outer membrane. Lipid A modification enzymes are reporters for lipopolysaccharide trafficking within the bacterial envelope. Modification systems are variable and often regulated by environmental conditions. Although not required for growth, the modification enzymes modulate virulence of some gram-negative pathogens. Heterologous expression of lipid A modification enzymes may enable the development of new vaccines.

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2007-07-07
2024-03-28
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Literature Cited

  1. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AHJ. et al. 2005. J. Lipid Res. 46:839–62
  2. Raetz CRH, Whitfield C. 2002. Annu. Rev. Biochem. 71:635–700
  3. Brade H, Opal SM, Vogel SN, Morrison DC. eds. 1999. Endotoxin in Health and Disease New York: Marcel Dekker.950 pp
  4. Nikaido H. 2003. Microbiol. Mol. Biol. Rev. 67:593–656
  5. Galloway SM, Raetz CRH. 1990. J. Biol. Chem. 265:6394–402
  6. Guan Z, Breazeale SD, Raetz CRH. 2005. Anal. Biochem. 345:336–39
  7. Steeghs L, de Cock H, Evers E, Zomer B, Tommassen J, van der Ley P. 2001. EMBO J. 20:6937–45
  8. Meredith TC, Aggarwal P, Mamat U, Lindner B, Woodard RW. 2006. ACS Chem. Biol. 1:33–42
  9. Belunis CJ, Clementz T, Carty SM, Raetz CRH. 1995. J. Biol. Chem. 270:27646–52
  10. Onishi HR, Pelak BA, Gerckens LS, Silver LL, Kahan FM. et al. 1996. Science 274:980–82
  11. Bos MP, Robert V, Tommassen J. 2007. Annu. Rev. Microbiol. 61: In press [Google Scholar]
  12. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV. et al. 1998. Science 282:2085–88
  13. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T. et al. 1999. J. Immunol. 162:3749–52
  14. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K. et al. 1999. J. Exp. Med. 189:1777–82
  15. Gangloff M, Gay NJ. 2004. Trends Biochem. Sci. 29:294–300
  16. Miller SI, Ernst RK, Bader MW. 2005. Nat. Rev. Microbiol. 3:36–46
  17. Visintin A, Halmen KA, Latz E, Monks BG, Golenbock DT. 2005. J. Immunol. 175:6465–72
  18. Akira S, Uematsu S, Takeuchi O. 2006. Cell 124:783–801
  19. Beutler B, Cerami A. 1988. Annu. Rev. Biochem. 57:505–18
  20. Dinarello CA. 1991. Blood 77:1627–52
  21. Medzhitov R, Janeway CJ. 2000. N. Engl. J. Med. 343:338–44
  22. van Duin D, Medzhitov R, Shaw AC. 2006. Trends Immunol. 27:49–55
  23. Li A, Chang AC, Peer GT, Hinshaw LB, Taylor FBJ. 1996. Shock 5:274–79
  24. Drake TA, Cheng J, Chang A, Taylor FBJ. 1993. Am. J. Pathol. 142:1458–70
  25. Parillo JE. 1993. N. Engl. J. Med. 328:1471–77
  26. Russell JA. 2006. N. Engl. J. Med. 355:1699–713
  27. Rietschel ET, Kirikae T, Schade FU, Mamat U, Schmidt G. et al. 1994. FASEB J. 8:217–25
  28. Prabhakar U, Conway TM, Murdock P, Mooney JL, Clark S. et al. 2005. DNA Cell Biol. 24:410–31
  29. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV. et al. 2005. Nature 437:1032–37
  30. Qureshi N, Takayama K, Ribi E. 1982. J. Biol. Chem. 257:11808–15
  31. Persing DH, Coler RN, Lacy MJ, Johnson DA, Baldridge JR. et al. 2002. Trends Microbiol. 10:S32–37
  32. Baldridge JR, McGowan P, Evans JT, Cluff C, Mossman S. et al. 2004. Expert. Opin. Biol. Ther. 4:1129–38
  33. Takayama K, Qureshi N, Beutler B, Kirkland TN. 1989. Infect. Immun. 57:1336–38
  34. Golenbock DT, Hampton RY, Qureshi N, Takayama K, Raetz CRH. 1991. J. Biol. Chem. 266:19490–98
  35. Christ WJ, Asano O, Robidoux AL, Perez M, Wang Y. et al. 1995. Science 265:80–83
  36. Hawkins LD, Christ WJ, Rossignol DP. 2004. Curr. Top. Med. Chem. 4:1147–71
  37. Lynn M, Rossignol DP, Wheeler JL, Kao RJ, Perdomo CA. et al. 2003. J. Infect. Dis. 187:631–39
  38. Bell JK, Botos I, Hall PR, Askins J, Shiloach J. et al. 2005. Proc. Natl. Acad. Sci. USA 102:10976–80
  39. Choe J, Kelker MS, Wilson IA. 2005. Science 309:581–85
  40. Bell JK, Askins J, Hall PR, Davies DR, Segal DM. 2006. Proc. Natl. Acad. Sci. USA 103:8792–97
  41. Raetz CRH. 1990. Annu. Rev. Biochem. 59:129–70
  42. Gunn JS, Lim KB, Krueger J, Kim K, Guo L. et al. 1998. Mol. Microbiol. 27:1171–82
  43. Guo L, Lim KB, Gunn JS, Bainbridge B, Darveau RP. et al. 1997. Science 276:250–53
  44. Groisman EA. 2001. J. Bacteriol. 183:1835–42
  45. Gibbons HS, Kalb SR, Cotter RJ, Raetz CRH. 2005. Mol. Microbiol. 55:425–40
  46. Bader MW, Sanowar S, Daley ME, Schneider AR, Cho U. et al. 2005. Cell 122:461–72
  47. Bishop RE, Gibbons HS, Guina T, Trent MS, Miller SI, Raetz CRH. 2000. EMBO J. 19:5071–80
  48. Trent MS, Ribeiro AA, Lin S, Cotter RJ, Raetz CRH. 2001. J. Biol. Chem. 276:43122–31
  49. Trent MS, Ribeiro AA, Doerrler WT, Lin S, Cotter RJ, Raetz CRH. 2001. J. Biol. Chem. 276:43132–44
  50. Trent MS, Pabich W, Raetz CRH, Miller SI. 2001. J. Biol. Chem. 276:9083–92
  51. Trent MS, Raetz CRH. 2002. J. Endotoxin Res. 8:158
  52. Tran AX, Karbarz MJ, Wang X, Raetz CRH, McGrath SC. et al. 2004. J. Biol. Chem. 279:55780–91
  53. Lee H, Hsu FF, Turk J, Groisman EA. 2004. J. Bacteriol. 186:4124–33
  54. Reynolds CM, Kalb SR, Cotter RJ, Raetz CRH. 2005. J. Biol. Chem. 280:21202–11
  55. Reynolds CM, Ribeiro AA, McGrath SC, Cotter RJ, Raetz CRH, Trent MS. 2006. J. Biol. Chem. 281:21974–87
  56. Doerrler WT, Gibbons HS, Raetz CRH. 2004. J. Biol. Chem. 279:45102–9
  57. Bos MP, Tefsen B, Geurtsen J, Tommassen J. 2004. Proc. Natl. Acad. Sci. USA 101:9417–22
  58. Jia W, Zoeiby AE, Petruzziello TN, Jayabalasingham B, Seyedirashti S, Bishop RE. 2004. J. Biol. Chem. 279:44966–75
  59. Wang X, Karbarz MJ, McGrath SC, Cotter RJ, Raetz CRH. 2004. J. Biol. Chem. 279:49470–78
  60. Wang X, McGrath SC, Cotter RJ, Raetz CRH. 2006. J. Biol. Chem. 281:9321–30
  61. Wu T, McCandlish AC, Gronenberg LS, Chng SS, Silhavy TJ, Kahne D. 2006. Proc. Natl. Acad. Sci. USA 103:11754–59
  62. Nishijima M, Raetz CRH. 1979. J. Biol. Chem. 254:7837–44
  63. Takayama K, Qureshi N, Mascagni P, Nashed MA, Anderson L, Raetz CRH. 1983. J. Biol. Chem. 258:7379–85
  64. Bulawa CE, Raetz CRH. 1984. J. Biol. Chem. 259:4846–51
  65. Imoto M, Kusumoto S, Shiba T, Naoki H, Iwashita T. et al. 1983. Tetrahedron Lett. 24:4017–20
  66. Strain SM, Fesik SW, Armitage IM. 1983. J. Biol. Chem. 258:13466–77
  67. Galanos C, Lüderitz O, Rietschel ET, Westphal O, Brade H. et al. 1985. Eur. J. Biochem. 148:1–5
  68. Anderson MS, Bulawa CE, Raetz CRH. 1985. J. Biol. Chem. 260:15536–41
  69. Ray BL, Painter G, Raetz CRH. 1984. J. Biol. Chem. 259:4852–59
  70. Riley M, Abe T, Arnaud MB, Berlyn MK, Blattner FR. et al. 2006. Nucleic Acids Res. 34:1–9
  71. Krziwon C, Zähringer U, Kawahara K, Weidemann B, Kusumoto S. et al. 1995. Infect. Immun. 63:2899–905
  72. Wheeler DL, Church DM, Federhen S, Lash AE, Madden TL. et al. 2003. Nucleic Acids Res. 31:28–33
  73. Anderson MS, Bull HS, Galloway SM, Kelly TM, Mohan S. et al. 1993. J. Biol. Chem. 268:19858–65
  74. Kelly TM, Stachula SA, Raetz CRH, Anderson MS. 1993. J. Biol. Chem. 268:19866–74
  75. Young K, Silver LL, Bramhill D, Cameron P, Eveland SS. et al. 1995. J. Biol. Chem. 270:30384–91
  76. Radika K, Raetz CRH. 1988. J. Biol. Chem. 263:14859–67
  77. Babinski KJ, Kanjilal SJ, Raetz CRH. 2002. J. Biol. Chem. 277:25947–56
  78. Babinski KJ, Ribeiro AA, Raetz CRH. 2002. J. Biol. Chem. 277:25937–46
  79. Garrett TA, Kadrmas JL, Raetz CRH. 1997. J. Biol. Chem. 272:21855–64
  80. Clementz T, Bednarski JJ, Raetz CRH. 1996. J. Biol. Chem. 271:12095–102
  81. Clementz T, Zhou Z, Raetz CRH. 1997. J. Biol. Chem. 272:10353–60
  82. Carty SM, Sreekumar KR, Raetz CRH. 1999. J. Biol. Chem. 274:9677–85
  83. Vorachek-Warren MK, Ramirez S, Cotter RJ, Raetz CRH. 2002. J. Biol. Chem. 277:14194–205
  84. Liu D, Sun TP, Raetz CRH. 2003. FASEB J. 17:(Suppl. S, Pt. 1) A579
  85. Armstrong MT, Theg SM, Braun N, Wainwright N, Pardy RL, Armstrong PB. 2006. FASEB J. 20:2145–46
  86. Anderson MS, Raetz CRH. 1987. J. Biol. Chem. 262:5159–69
  87. Williamson JM, Anderson MS, Raetz CRH. 1991. J. Bacteriol. 173:3591–96
  88. Wyckoff TJO, Lin S, Cotter RJ, Dotson GD, Raetz CRH. 1998. J. Biol. Chem. 273:32369–72
  89. Odegaard TJ, Kaltashov IA, Cotter RJ, Steeghs L, van der Ley P. et al. 1997. J. Biol. Chem. 272:19688–96
  90. Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR. et al. 2004. J. Biol. Chem. 279:25411–19
  91. Dotson GD, Kaltashov IA, Cotter RJ, Raetz CRH. 1998. J. Bacteriol. 180:330–37
  92. Raetz CRH, Roderick SL. 1995. Science 270:997–1000
  93. Lee BI, Suh SW. 2003. Proteins 53:772–74
  94. Williams AH, Immormino RM, Gewirth DT, Raetz CRH. 2006. Proc. Natl. Acad. Sci. USA 103:10877–82
  95. Wyckoff TJ, Raetz CRH. 1999. J. Biol. Chem. 274:27047–55
  96. Weckesser J, Mayer H. 1988. FEMS Microbiol Rev 4:143–53
  97. Sweet CR, Ribeiro AA, Raetz CRH. 2004. J. Biol. Chem. 279:25400–10
  98. Que-Gewirth NLS, Ribeiro AA, Kalb SR, Cotter RJ, Bulach DM. et al. 2004. J. Biol. Chem. 279:25420–29
  99. Anderson MS, Robertson AD, Macher I, Raetz CRH. 1988. Biochemistry 27:1908–17
  100. Jackman JE, Raetz CRH, Fierke CA. 1999. Biochemistry 38:1902–11
  101. Jackman JE, Raetz CRH, Fierke CA. 2001. Biochemistry 40:514–23
  102. Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T. et al. 2000. J. Biol. Chem. 275:11002–9
  103. Clements JM, Coignard F, Johnson I, Chandler S, Palan S. et al. 2002. Antimicrob. Agents Chemother. 46:1793–99
  104. McClerren AL, Endsley S, Bowman JL, Andersen NH, Guan Z. et al. 2005. Biochemistry 44:16574–83
  105. Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW. 2003. Proc. Natl. Acad. Sci. USA 100:8146–50
  106. Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA. 2005. J. Biol. Chem. 280:16969–78
  107. Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW. 2006. Biochemistry 45:7940–48
  108. Gennadios HA, Christianson DW. 2006. Biochemistry 45:15216–23
  109. Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CRH, Zhou P. 2003. Nat. Struct. Biol. 10:645–51
  110. Coggins BE, McClerren AL, Jiang L, Li X, Rudolph J. et al. 2005. Biochemistry 44:1114–26
  111. Sorensen PG, Lutkenhaus J, Young K, Eveland SS, Anderson MS, Raetz CRH. 1996. J. Biol. Chem. 271:25898–905
  112. Fuhrer F, Langklotz S, Narberhaus F. 2006. Mol. Microbiol. 59:1025–36
  113. Ogura T, Inoue K, Tatsuta T, Suzaki T, Karata K. et al. 1999. Mol. Microbiol. 31:833–44
  114. Buetow L, Smith TK, Dawson A, Fyffe S, Hunter WN. 2007. Proc. Natl. Acad. Sci. USA 104:4321–26
  115. Hu Y, Chen L, Ha S, Gross B, Falcone B. et al. 2003. Proc. Natl. Acad. Sci. USA 100:845–49
  116. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z. et al. 1997. Nucleic Acids Res. 25:3389–402
  117. Haselberger A, Hildebrandt J, Lam C, Liehl E, Loibner H. et al. 1987. Triangle 26:33–49
  118. Scholz D, Bednarik K, Ehn G, Neruda W, Janzek E. et al. 1992. J. Med. Chem. 35:2070–74
  119. Albers U, Reus K, Shuman HA, Hilbi H. 2005. Microbiology 151:167–82
  120. Garrett TA, Que NL, Raetz CRH. 1998. J. Biol. Chem. 273:12457–65
  121. Belunis CJ, Raetz CRH. 1992. J. Biol. Chem. 267:9988–97
  122. Clementz T, Raetz CRH. 1991. J. Biol. Chem. 266:9687–96
  123. Brozek KA, Raetz CRH. 1990. J. Biol. Chem. 265:15410–17
  124. Ray BL, Raetz CRH. 1987. J. Biol. Chem. 262:1122–28
  125. Lien E, Means TK, Heine H, Yoshimura A, Kusumoto S. et al. 2000. J. Clin. Investig. 105:497–504
  126. Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler B. 2000. Proc. Natl. Acad. Sci. USA 97:2163–67
  127. Saitoh S, Akashi S, Yamada T, Tanimura N, Kobayashi M. et al. 2004. Int. Immunol. 16:961–69
  128. Brozek KA, Hosaka K, Robertson AD, Raetz CRH. 1989. J. Biol. Chem. 264:6956–66
  129. Meredith TC, Woodard RW. 2003. J. Biol. Chem. 278:32771–77
  130. Sperandeo P, Pozzi C, Deho G, Polissi A. 2006. Res. Microbiol. 157:547–58
  131. White KA, Kaltashov IA, Cotter RJ, Raetz CRH. 1997. J. Biol. Chem. 272:16555–63
  132. White KA, Lin S, Cotter RJ, Raetz CR. 1999. J. Biol. Chem. 274:31391–400
  133. Brabetz W, Muller-Loennies S, Brade H. 2000. J. Biol. Chem. 275:34954–62
  134. Isobe T, White KA, Allen AG, Peacock M, Raetz CRH, Maskell DJ. 1999. J. Bacteriol. 181:2648–51
  135. Belunis CJ, Mdluli KE, Raetz CRH, Nano FE. 1992. J. Biol. Chem. 267:18702–7
  136. Karow M, Georgopoulos C. 1992. J. Bacteriol. 174:702–10
  137. Murray SR, Bermudes D, de Felipe KS, Low KB. 2001. J. Bacteriol. 183:5554–61
  138. Somerville JJE, Cassiano L, Bainbridge B, Cunningham MD, Darveau RP. 1996. J. Clin. Investig. 97:359–65
  139. Low KB, Ittensohn M, Le T, Platt J, Sodi S. et al. 1999. Nat. Biotechnol. 17:37–41
  140. D’Hauteville H, Khan S, Maskell DJ, Kussak A, Weintraub A. et al. 2002. J. Immunol. 168:5240–51
  141. Vorachek-Warren MK, Carty SM, Lin S, Cotter RJ, Raetz CRH. 2002. J. Biol. Chem. 277:14186–93
  142. Montminy SW, Khan N, McGrath S, Walkowicz MJ, Sharp F. et al. 2006. Nat. Immunol. 7:1066–73
  143. Ferguson AD, Hofmann E, Coulton JW, Diederichs K, Welte W. 1998. Science 282:2215–20
  144. Ferguson AD, Welte W, Hofmann E, Lindner B, Holst O. et al. 2000. Struct. Fold. Des. 8:585–92
  145. Nishiyama K, Ikegami A, Moser M, Schiltz E, Tokuda H, Muller M. 2006. J. Biol. Chem. 281:35667–76
  146. Steeghs L, den Hartog R, den Boer A, Zomer B, Roholl P, van der Ley P. 1998. Nature 392:449–50
  147. Doerrler WT, Reedy MC, Raetz CRH. 2001. J. Biol. Chem. 276:11461–64
  148. Karow M, Georgopoulos C. 1993. Mol. Microbiol. 7:69–79
  149. Polissi A, Georgopoulos C. 1996. Mol. Microbiol. 20:1221–33
  150. Zhou Z, White KA, Polissi A, Georgopoulos C, Raetz CRH. 1998. J. Biol. Chem. 273:12466–75
  151. Chang G, Roth CB. 2001. Science 293:1793–800
  152. Chang G. 2003. J. Mol. Biol. 330:419–30
  153. Reyes CL, Chang G. 2005. Science 308:1028–31
  154. Dawson RJ, Locher KP. 2006. Nature 443:180–85
  155. Chang G, Roth CB, Reyes CL, Pornillos O, Chen YJ, Chen AP. 2006. Science 314:1875
  156. Raetz CRH, Garrett TA, Reynolds CM, Shaw WA, Moore JD. et al. 2006. J. Lipid Res. 47:1097–11
  157. Huijbregts RP, de Kroon AI, de Kruijff B. 1998. J. Biol. Chem. 273:18936–42
  158. Doerrler WT, Raetz CRH. 2002. J. Biol. Chem. 277:36697–705
  159. Kol MA, van Dalen A, de Kroon AI, de Kruijff B. 2003. J. Biol. Chem. 278:24586–93
  160. Venter JC, Remington K, Heidelberg JF, Halpern AL, Rusch D. et al. 2004. Science 304:66–74
  161. Osborn MJ, Rick PD, Rasmussen NS. 1980. J. Biol. Chem. 255:4246–51
  162. Tefsen B, Bos MP, Beckers F, Tommassen J, de Cock H. 2005. J. Biol. Chem. 280:35961–66
  163. Sperandeo P, Cescutti R, Villa R, Di Benedetto C, Candia D. et al. 2007. J. Bacteriol. 189:244–53
  164. Braun M, Silhavy TJ. 2002. Mol. Microbiol. 45:1289–302
  165. Borst P, Zelcer N, van Helvoort A. 2000. Biochim. Biophys. Acta 1486:128–44
  166. Borst P, Elferink RO. 2002. Annu. Rev. Biochem. 71:537–92
  167. Smit JJM, Schinkel AH, Oude Elferink RPJ, Groen AK, Wagenaar E. et al. 1993. Cell 75:451–62
  168. Schmitz G, Liebisch G, Langmann T. 2006. FEBS Lett. 580:5597–610
  169. Zhou Z, Lin S, Cotter RJ, Raetz CRH. 1999. J. Biol. Chem. 274:18503–14
  170. Zhou Z, Ribeiro AA, Lin S, Cotter RJ, Miller SI, Raetz CRH. 2001. J. Biol. Chem. 276:43111–21
  171. Brozek KA, Bulawa CE, Raetz CRH. 1987. J. Biol. Chem. 262:5170–79
  172. Guo L, Lim KB, Poduje CM, Daniel M, Gunn JS. et al. 1998. Cell 95:189–98
  173. Helander IM, Kilpeläinen I, Vaara M. 1994. Mol. Microbiol. 11:481–87
  174. Nummila K, Kilpeläinen I, Zähringer U, Vaara M, Helander IM. 1995. Mol. Microbiol. 16:271–78
  175. Helander IM, Kato Y, Kilpelainen I, Kostiainen R, Lindner B. et al. 1996. Eur. J. Biochem. 237:272–78
  176. Breazeale SD, Ribeiro AA, Raetz CRH. 2002. J. Biol. Chem. 277:2886–96
  177. Breazeale SD, Ribeiro AA, Raetz CRH. 2003. J. Biol. Chem. 279:24731–39
  178. Breazeale SD, Ribeiro AA, McClerren AL, Raetz CRH. 2005. J. Biol. Chem. 280:14154–67
  179. Williams GJ, Breazeale SD, Raetz CRH, Naismith JH. 2005. J. Biol. Chem. 280:23000–8
  180. Gatzeva-Topalova PZ, May AP, Sousa MC. 2005. Structure 13:929–42
  181. Noland BW, Newman JM, Hendle J, Badger J, Christopher JA. et al. 2002. Structure 10:1569–80
  182. Gunn JS, Ryan SS, Van Velkinburgh JC, Ernst RK, Miller SI. 2000. Infect. Immun. 68:6139–46
  183. Kanipes MI, Lin S, Cotter RJ, Raetz CRH. 2001. J. Biol. Chem. 276:1156–63
  184. Figueroa-Bossi N, Lemire S, Maloriol D, Balbontin R, Casadesus J, Bossi L. 2006. Mol. Microbiol. 62:838–52
  185. Tamayo R, Choudhury B, Septer A, Merighi M, Carlson R, Gunn JS. 2005. J. Bacteriol. 187:3391–99
  186. Kim SH, Jia W, Parreira VR, Bishop RE, Gyles CL. 2006. Microbiology 152:657–66
  187. Kim SH, Jia W, Bishop RE, Gyles C. 2004. Infect. Immun. 72:1174–80
  188. Kaniuk NA, Vinogradov E, Li J, Monteiro MA, Whitfield C. 2004. J. Biol. Chem. 279:31237–50
  189. El Ghachi M, Derbise A, Bouhss A, Mengin-Lecreulx D. 2005. J. Biol. Chem. 280:18689–95
  190. Lazar K, Walker S. 2002. Curr. Opin. Chem. Biol. 6:786–93
  191. Cho US, Bader MW, Amaya MF, Daley ME, Klevit RE. et al. 2006. J. Mol. Biol. 356:1193–206
  192. Martin-Orozco N, Touret N, Zaharik ML, Park E, Kopelman R. et al. 2006. Mol. Biol. Cell 17:498–510
  193. Winfield MD, Groisman EA. 2004. Proc. Natl. Acad. Sci. USA 101:17162–67
  194. Guina T, Yi EC, Wang H, Hackett M, Miller SI. 2000. J. Bacteriol. 182:4077–86
  195. Robey M, O’Connell W, Cianciotto NP. 2001. Infect. Immun. 69:4276–86
  196. Preston A, Maxim E, Toland E, Pishko EJ, Harvill ET. et al. 2003. Mol. Microbiol. 48:725–36
  197. Pilione MR, Pishko EJ, Preston A, Maskell DJ, Harvill ET. 2004. Infect. Immun. 72:2837–42
  198. Bishop RE. 2005. Mol. Microbiol. 57:900–12
  199. Rebeil R, Ernst RK, Gowen BB, Miller SI, Hinnebusch BJ. 2004. Mol. Microbiol. 52:1363–73
  200. Ahn VE, Lo EI, Engel CK, Chen L, Hwang PM. et al. 2004. EMBO J. 23:2931–41
  201. Hwang PM, Choy WY, Lo EI, Chen L, Forman-Kay JD. et al. 2002. Proc. Natl. Acad. Sci. USA 99:13560–65
  202. Evanics F, Hwang PM, Cheng Y, Kay LE, Prosser RS. 2006. J. Am. Chem. Soc. 128:8256–64
  203. Khan MA, Neale C, Michaux C, Pomès R, Privé GG. et al. 2007. Biochemistry 46:4565–79
  204. Stover AG, Da Silva Correia J, Evans JT, Cluff CW, Elliott MW. et al. 2004. J. Biol. Chem. 279:4440–509
  205. Hwang PM, Bishop RE, Kay LE. 2004. Proc. Natl. Acad. Sci. USA 101:9618–23
  206. Tam C, Missiakas D. 2005. Mol. Microbiol. 55:1403–12
  207. Gibbons HS, Lin S, Cotter RJ, Raetz CRH. 2000. J. Biol. Chem. 275:32940–49
  208. Raetz CRH. 2001. J. Endotoxin Res. 7:73–78
  209. Kawasaki K, Ernst RK, Miller SI. 2005. J. Bacteriol. 187:2448–57
  210. Geurtsen J, Steeghs L, Hamstra HJ, Ten Hove J, de Haan A. et al. 2006. Infect. Immun. 74:5574–85
  211. Kawasaki K, Ernst RK, Miller SI. 2004. J. Biol. Chem. 279:20044–48
  212. Ernst RK, Adams KN, Moskowitz SM, Kraig GM, Kawasaki K. et al. 2006. J. Bacteriol. 188:191–201
  213. Geurtsen J, Steeghs L, Hove JT, van der Ley P, Tommassen J. 2005. J. Biol. Chem. 280:8248–59
  214. Rutten L, Geurtsen J, Lambert W, Smolenaers JJ, Bonvin AM. et al. 2006. Proc. Natl. Acad. Sci. USA 103:7071–76
  215. Ellis J, Oyston PC, Green M, Titball RW. 2002. Clin. Microbiol. Rev. 15:631–46
  216. Kieffer TL, Cowley S, Nano FE, Elkins KL. 2003. Microb. Infect. 5:397–403
  217. Wang X, Ribeiro AA, Guan Z, McGrath S, Cotter R, Raetz CRH. 2006. Biochemistry 45:14427–40
  218. Larsson P, Oyston PC, Chain P, Chu MC, Duffield M. et al. 2005. Nat. Genet. 37:153–59
  219. Stead C, Tran A, Ferguson DJ, McGrath S, Cotter R, Trent S. 2005. J. Bacteriol. 187:3374–83
  220. Phillips NJ, Schilling B, McLendon MK, Apicella MA, Gibson BW. 2004. Infect. Immun. 72:5340–48
  221. Vinogradov E, Perry MB, Conlan JW. 2002. Eur. J. Biochem. 269:6112–18
  222. Wang X, Ribeiro AA, Guan Z, Abraham SN, Raetz CRH. 2007. Proc. Natl. Acad. Sci. USA 104:4136–41
  223. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG. et al. 1997. Nature 388:539–47
  224. Bhat UR, Forsberg LS, Carlson RW. 1994. J. Biol. Chem. 269:14402–10
  225. Que NLS, Lin S, Cotter RJ, Raetz CRH. 2000. J. Biol. Chem. 275:28006–16
  226. Que NLS, Ribeiro AA, Raetz CRH. 2000. J. Biol. Chem. 275:28017–27
  227. Bhat UR, Mayer H, Yokota A, Hollingsworth RI, Carlson R. 1991. J. Bacteriol. 173:2155–59
  228. Basu SS, White KA, Que NL, Raetz CRH. 1999. J. Biol. Chem. 274:11150–58
  229. Carlson RW, Reuhs B, Chen TB, Bhat UR, Noel KD. 1995. J. Biol. Chem. 270:11783–88
  230. Brozek KA, Kadrmas JL, Raetz CRH. 1996. J. Biol. Chem. 271:32112–18
  231. Price NPJ, Kelly TM, Raetz CRH, Carlson RW. 1994. J. Bacteriol. 176:4646–55
  232. Basu SS, Karbarz MJ, Raetz CRH. 2002. J. Biol. Chem. 277:28959–71
  233. Brozek KA, Carlson RW, Raetz CRH. 1996. J. Biol. Chem. 271:32126–36
  234. Karbarz MJ, Kalb SR, Cotter RJ, Raetz CRH. 2003. J. Biol. Chem. 278:39269–79
  235. Que-Gewirth NLS, Lin S, Cotter RJ, Raetz CRH. 2003. J. Biol. Chem. 278:12109–19
  236. Que-Gewirth NLS, Karbarz MJ, Kalb SR, Cotter RJ, Raetz CRH. 2003. J. Biol. Chem. 278:12120–29
  237. Kanjilal-Kolar S, Basu SS, Kanipes MI, Guan Z, Garrett TA, Raetz CRH. 2006. J. Biol. Chem. 281:12865–78
  238. Kanjilal-Kolar S, Raetz CRH. 2006. J. Biol. Chem. 281:12879–87
  239. Ferguson GP, Datta A, Carlson RW, Walker GC. 2005. Mol. Microbiol. 56:68–80
  240. Vedam V, Kannenberg EL, Haynes JG, Sherrier DJ, Datta A, Carlson RW. 2003. J. Bacteriol. 185:1841–50
  241. Boon Hinckley M, Reynolds CM, Ribeiro AA, McGrath SC, Cotter RJ. et al. 2005. J. Biol. Chem. 280:30214–24
  242. Vinogradov EV, Muller-Loennies S, Petersen BO, Meshkov S, Thomas-Oates JE. et al. 1997. Eur. J. Biochem. 247:82–90
  243. Bode CE, Brabetz W, Brade H. 1998. Eur. J. Biochem. 254:404–12
  244. Schneider JE, Reinhold V, Rumley MK, Kennedy EP. 1979. J. Biol. Chem. 254:10135–38
  245. Kennedy EP. 1987. In Escherichia coli and Salmonella typhimurium ed. FC Neidhardt pp. 672–79 Vol I. Washington, DC: ASM Publ.
  246. Wu HC. 1996. In Escherichia coli and Salmonella: Cellular and Molecular Biology ed. FC Neidhardt pp. 1005–14 Washington, DC: Am. Soc. Microbiol.
  247. Raetz CRH. 1986. Annu. Rev. Genet. 20:253–95
  248. Cronan JE. 2003. Annu. Rev. Microbiol. 57:203–24
  249. Stevenson G, Neal B, Liu D, Hobbs M, Packer NH. et al. 1994. J. Bacteriol. 176:4144–56
  250. Murphy RC, Raetz CRH, Reynolds CM, Barkley RM. 2005. Prostaglandins Other Lipid Mediat. 77:131–40
  251. Jain NU, Wyckoff TJ, Raetz CRH, Prestegard JH. 2004. J. Mol. Biol. 343:1379–89
  252. Feldman MF, Marolda CL, Monteiro MA, Perry MB, Parodi AJ, Valvano MA. 1999. J. Biol. Chem. 274:35129–38
  253. Strain SM, Armitage IM, Anderson L, Takayama K, Qureshi N, Raetz CRH. 1985. J. Biol. Chem. 260:16089–98
  254. Zhou Z, Ribeiro AA, Raetz CRH. 2000. J. Biol. Chem. 275:13542–51
  255. Price NJP, Jeyaretnam B, Carlson RW, Kadrmas JL, Raetz CRH, Brozek KA. 1995. Proc. Natl. Acad. Sci. USA 92:7352–56
  256. Kadrmas JL, Brozek KA, Raetz CRH. 1996. J. Biol. Chem. 271:32119–25
  257. Kadrmas JL, Allaway D, Studholme RE, Sullivan JT, Ronson CW. et al. 1998. J. Biol. Chem. 273:26432–40
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