1932

Abstract

Abstract

Cell death plays many roles during development, in the adult, and in the genesis of many pathological states. Much of this death is apoptotic in nature and requires the activity of members of the caspase family of proteases. It is now possible uniquely in to carry out genetic screens for genes that determine the fate—life or death—of any population of cells during development and adulthood. This, in conjunction with the ability to obtain biochemical quantities of material, has made a useful organism for exploring the mechanisms by which apoptosis is carried out and regulated. This review summarizes our knowledge of caspase-dependent cell death in and compares that knowledge with what is known in worms and mammals. We also discuss the significance of recent work showing that a number of key cell death activators also play nonapoptotic roles. We highlight opportunities and outstanding questions along the way.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.cellbio.21.012804.093845
2006-11-10
2024-03-28
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.cellbio.21.012804.093845
Loading
/content/journals/10.1146/annurev.cellbio.21.012804.093845
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error