Skip to main content
  • Research article
  • Open access
  • Published:

A systematic review of delay in the diagnosis and treatment of tuberculosis

Abstract

Background

Early diagnosis and immediate initiation of treatment are essential for an effective tuberculosis (TB) control program. Delay in diagnosis is significant to both disease prognosis at the individual level and transmission within the community. Most transmissions occur between the onset of cough and initiation of treatment.

Methods

A systematic review of 58 studies addressing delay in diagnosis and treatment of TB was performed. We found different definitions of, for example, debut of symptoms, first appropriate health care provider, time to diagnosis, and start of treatment. Rather than excluding studies that failed to meet strict scientific criteria (like in a meta-analysis), we tried to extract the "solid findings" from all of them to arrive on a more global understanding of diagnostic delay in TB.

Results

The main factors associated with diagnostic delay included human immunodeficiency virus; coexistence of chronic cough and/or other lung diseases; negative sputum smear; extrapulmonary TB; rural residence; low access (geographical or sociopsychological barriers); initial visitation of a government low-level healthcare facility, private practitioner, or traditional healer; old age; poverty; female sex; alcoholism and substance abuse; history of immigration; low educational level; low awareness of TB; incomprehensive beliefs; self-treatment; and stigma.

Conclusion

The core problem in delay of diagnosis and treatment seemed to be a vicious cycle of repeated visits at the same healthcare level, resulting in nonspecific antibiotic treatment and failure to access specialized TB services. Once generation of a specific diagnosis was in reach, TB treatment was initiated within a reasonable period of time.

Peer Review reports

Background

Until the last part of the twentieth century, tuberculosis (TB) was a major cause of death in both developed and developing countries. Due to a range of factors such as the human immunodeficiency virus (HIV) epidemic, population growth, migration, socioeconomic changes, and broad spread of aggressive and resistant new strains such as the Beijing and W strains, a resurgence of TB has occurred, even in low endemic areas [1]. In 1993, the World Health Organization (WHO) declared a state of global emergency for TB due to the steady worldwide increase in the disease. Along with HIV and malaria, TB has been declared a global enemy. In 2005, 12 million new cases of tuberculosis were identified, a 58% increase from the 7.5 million estimated cases in 1990, and it was estimated that in 2005 the disease caused 1.5 million deaths worldwide [2].

The goal of TB control programs is to arrest transmission within the community. Achieving this goal takes considerable time, because most individuals in endemic areas are already infected, constituting a reservoir that continuously contributes to the pool of infectious cases. An effective TB control program requires early diagnosis and immediate initiation of treatment. Delay in diagnosis is significant with regard to not only disease prognosis at the individual level but also transmission within the community and the reproductive rate of the TB epidemic [3, 4]. Most transmissions occur between the appearance of cough and initiation of treatment. Madebo et al found that patients become more contagious as the delay progresses; the longest delays are associated with the highest bacillary numbers on sputum smears [5]. Because TB symptoms, particularly chronic cough with sputum, are so prevalent in most societies, early contact with health services causes delay rather than suspicion of TB. We found that in Ethiopia patients with TB symptoms contact an educated health worker on average after just 25% of the total delay period [6]. Thus, there is a fourfold-difference in the time of first contact and diagnosis.

Analysis of the factors leading to this delay between first contact and diagnosis is crucial to combatting the increasing TB epidemic. Although there are multiple studies of delayed TB diagnosis, no one has performed a systematic review.

Methods

Search strategy

We searched the following databases using the search terms and strategy described in Table 1: the Cochrane Infectious Diseases Group Specialized Register (February 2007); the Cochrane Central Register of Controlled Trials (CENTRAL) published in The Cochrane Library (February 2007); MEDLINE (1966 to February 2007); EMBASE (1974 to February 2007); and LILACS (1982 to February 2007). In addition, to identify unpublished and ongoing studies, we contacted individual researchers in the TB field as well as the WHO (2006) and the International Union Against Tuberculosis and Lung Disease (IUATLD, 2006).

Table 1 Search terms and strategy

Selection and analysis

Only observational studies were selected. All obtainable studies of patients receiving treatment for active pulmonary TB that recorded at least the median or mean total delay in diagnosis were included. The outcomes of interest were diagnostic delay from the debut of symptoms to the time of diagnosis or start of treatment. The titles and abstracts of the identified reports were used to exclude studies that clearly did not meet the inclusion criteria. For studies deemed potentially eligible for inclusion, we obtained the full paper. We screened the full articles of selected studies to confirm eligibility and resolved any disagreements by discussion. Our intent was not to exclude studies based on strict scientific criteria, or to perform a traditional quality assessment, but to make the studies as comparable as possible.

We analyzed the studies with the intent of identifying differences in approaches, rather than to define a gold standard. A primary aim was to describe the inevitable inaccuracy that arises from the use of different definitions of, for example, the debut of symptoms, first appropriate health care provider, time of diagnosis, and start of treatment.

Results

Search results

Our analysis revealed how complex it is to define diagnostic delay, and there were major differences between studies regarding inclusion and exclusion criteria, onset of symptoms, first contact and end of delay. First, the 58 studies used different inclusion criteria. Seventeen studies included all new TB cases, 11 included all pulmonary TB cases, 3 included all cases with a positive sputum smear, 24 included all new cases with a positive sputum spear, and for 3 studies data were not obtainable. Likewise, the study exclusion criteria differed. Some studies carefully excluded all cases with chronic underlying pulmonary conditions that could interfere with the patient's definition of symptom onset, but most did not. Some studies excluded visitors, mortal cases, and individuals with mental disturbances. The age-related exclusion criteria also varied: most studies excluded cases below the age of 16 years, some excluded cases below the age of 18 years, and a few included children of all ages. One study did not include patients who had undergone 2 or more months of treatment.

Definition of the onset of symptoms was also variable. Forty-nine studies defined onset as the debut of any symptom, 2 studies defined onset as debut of cough, and 1 study defined onset as debut of any pulmonary symptom. For 6 studies, a definition of symptom onset could not be obtained.

With regard to definition of the first contact, 34 studies defined the first contact as the first visit to a qualified healthcare provider. However, some of these studies included any allopathic ("western medicine") provider within the category of a qualified healthcare provider; others used the time of first contact with the national TB program in defining the end of patient delay. Eighteen studies defined the first contact as the time when the patient sought contact with any healthcare provider outside the household, including traditional practitioners. Four studies recorded both. Six studies did not provide any information with regard to definition of the first contact.

The studies also applied different definitions of the end of the delay. Seventeen studies defined the end of healthcare system delay as the time when a correct diagnosis was made (diagnostic delay), 20 studies defined it as the time the patient started treatment (treatment delay), and 14 studies distinctly recorded both. Data of this kind were unavailable for 7 studies.

Most studies defined the delay as a specific number of days, but several studies defined it as greater than a specific period of time (e.g. >60 days, > 90 days), or delay was defined as significantly longer in one group versus another group. A cut off point of 30 days to dichotomize into either delay on non delay was also commonly used.

Diagnostic delay

Table 2 lists the included studies in descending order according to the total diagnostic delay. Not surprisingly, the longest total delays (> 120 days) were reported for some high endemic countries, with the exception of the median 126-day delay reported by Lewis et al for East London [7]. Most of the studies, whether investigating low or high endemic countries, reported a total diagnostic delay within the range of 60–90 days (mean ± standard deviation: 72 days ± 28 days).

Table 2 Median diagnostic delay for pulmonary TB patients in 58 studies

There was no consistent pattern with regard to the relative contributions of patients and healthcare providers to the diagnostic delay. The main delay was patient related in the studies in London (Lewis et al), Romania, Vietnam, Nigeria, South Africa, Australia (Queensland), Ethiopia (Addis Abeba), Korea, Somalia, Syria, Turkey (Istanbul, Okur et al), Japan (Chiba), Iraq, USA (New York), Yemen, and China (Shanghai). The main cause of delay was identified as the healthcare system in the studies of Tanzania, Ghana, Pakistan, Malaysia, Iran (WHO, nationwide), Botswana, New Zealand, Uganda, Ethiopia (Amhara), Italy, and China (Jianhu). Twelve studies reported a nearly equal contribution of patients and healthcare system to the diagnostic delay. The remaining studies did not record the relative importance of these two factors in the diagnostic delay.

Symptoms prior to diagnosis

Twenty-five studies recorded the frequency of symptoms reported by patients before diagnosis. The average frequencies of the following five cardinal symptoms were (number of studies listing the symptom in brackets): cough 85% (25), fever 65% (24), weight loss 62% (22), chest symptoms 50% (24), and haemoptysis 25% (22). Other symptoms less frequently reported: sputum 67% (5), fatigue 55% (8), and increased sweating 35% (10). All but two studies defined the onset of patient delay from the debut of any symptom [8, 9], where the debut of cough defined the start.

Risk factors for prolonged diagnostic delay

The possible risk factors for diagnostic delay were heterogeneous (Table 3). The study conclusions were also heterogeneous; a risk factor for increased delay in some studies was a risk factor for decreased delay in other studies. Some factors were identified in numerous studies, while others were mentioned by only one study or a few studies. Following is a brief analysis of the factors, which are further elaborated in the "Discussion".

Table 3 Risk factors for diagnostic delay

Clinical characteristics

The WHO study in Syria found HIV to be a risk factor for increased delay in diagnosis [10], while three other studies concluded the opposite [11–13]. Four studies found coexistence of chronic cough and/or other lung diseases be a risk factor for increased delay [12, 14–16]; one study found the opposite [7]. Only a few studies included extrapulmonary TB, and as expected three found that patients with extrapulmonary TB experience longer delays than do patients with pulmonary TB [7, 17, 18]. Three studies found a negative sputum smear to be a risk factor for increased delay [12, 19, 20]; one study found the opposite (the WHO study in Egypt [15]). Six studies found alcoholism or substance abuse to be a risk factor for increased diagnostic delay [8, 21–25]. Other health-related risk factors identified include generally poor health [26], smoking [14, 23], coexistence of sexually transmitted diseases [26], less severe and indifferent symptoms [27], and absence of hemoptysis [16, 28].

Socioeconomic factors

A range of studies found rural residence to be a risk factor for prolonged delay [5, 11, 14, 16, 23, 25, 29–32]. This risk factor seems to be closely linked to low access to healthcare and choice of settings in which to first seek healthcare (see next section). Even among developing countries, access to healthcare varied. For example, in Ethiopia the public health service coverage was reported to be 50% [6], whereas in The Gambia 87% of the population was reported to have good access to healthcare [7, 19, 20, 32]. The studies provided broad evidence that low access leads to prolonged delay in diagnosis [5, 7, 9, 13, 17, 20, 27–33].

Sociopsychological factors

Seeking government low-level health care facility first [5, 6, 9–11, 23, 26, 32–34] (one study from Spain found the opposite [35]). Initially seeking a traditional or unqualified practitioner [9, 10, 14, 26–29, 32, 36, 37]. First seeking a private practitioner was a clear risk factor for diagnostic delay, independent of rural or urban residence [9–11, 14, 15, 19, 21, 23, 24, 26, 28, 35]. Four studies concluded that seeking specialized services leads to a decreased diagnostic delay [13, 23, 38, 39], while one study from the USA [11] found the opposite.

Sociodemographic factors

A range of studies found old age to be a risk factor for increased diagnostic delay [6, 13, 15–17, 20, 23, 25, 32, 37–39], while two studies found the opposite [18, 35]. Also, a number of studies concluded that females experience increased diagnostic delay [8, 10, 11, 14–16, 20, 27, 28, 30, 40, 41]. However, a substantial number of studies made the opposite conclusion [5, 21, 23, 25]. In addition, history of immigration or illegal residency seemed to be a risk factor in countries where this is actual [8, 15, 17, 22, 38, 39, 42].

Socioeconomic factors

Thirteen studies found low income and poverty to be a risk factor for diagnostic delay [3, 7, 17, 23, 24, 31, 34, 38, 39, 43–46]. In a range of studies, low educational level and/or low awareness and knowledge about TB was listed as a risk factor for diagnostic delay [5, 10, 16–18, 21, 23, 25, 27–29, 34, 37, 47, 48]. Only one, from France [13], determined the opposite, finding that low educational level was linked to immigration and socially deprived groups where the health authorities focused on TB.

Other socioeconomic risk factors identified by 1–3 studies included being married [5], being single [18, 26], large family size [30], being a farmer [5], being white (vs. aboriginal) [20], being a Muslim [18], belonging to an indigenous group [13], and not having insurance [13].

Beliefs and attitudes

Beliefs about TB (TB is incurable, caused by evil spirits, etc.) [8, 14, 27], stigma [27], and self-treatment [6, 36, 42] were identified as risk factors in 1–3 studies.

The vicious circle of repeated visits at the same level

A majority of the studies identified as the direct or underlying problem a vicious circle of repeated consultations with a multitude of healthcare providers without a correct diagnosis. Several papers list multiple visits at the same level, while others focus on multiple visits to the same physician. Three groups of healthcare providers were particularly identified as sources of this vicious circle: primary-level government health posts, who have limited diagnostic facilities and poorly trained personnel [5, 6, 9–11, 23, 26, 32–34]; private practitioners with low awareness of TB [9–11, 14, 15, 19, 21, 23, 25, 26, 29, 32]; and unqualified vendors, quacks, and traditional practitioners [9, 10, 14, 26–29, 32, 36, 37] In Burkina Faso for a patient seeking a health post or a private practitioner, the progression towards specialized services was poor; patients had repeated consultations at the same level, such that more than 94% of patients underwent repeated courses of nonspecific antibiotics [49]. In Ghana, the health personnel at government health posts have poor training in diagnosing TB, and the specialized services of the NTP are overcentralized [11]. In a study in Malaysia, only 11% of patients received their diagnosis after the first consultation, and 45% received their first diagnosis after the third consultation [21]. Another study from Malaysia similarly indicates low awareness of the private practitioner as a key problem [36].

Discussion

The studies had different definitions of a range of variables, for example, debut of symptoms, first appropriate health care provider, time to diagnosis, and start of treatment, and they were not directly comparable or suited for a meta-analysis. Rather than excluding studies that failed to meet strict scientific criteria (like in a meta-analysis), we tried to extract the "solid findings" from all of them to arrive on a more global understanding of diagnostic delay in TB. Our detailed analysis demonstrates that the interacting factors affecting patients' health-seeking behavior and the availability of TB treatment can be categorized as involving either the patient or healthcare. Most factors influence both patient and health care delay, but some factors were more closely related to patient delay: alcohol or substance abuse, poverty, low access to health care facilities, rural residence, old age, belonging to an indigenous group and incomprehensive attitudes, beliefs and knowledge about TB. Other factors were evidently more linked to health care delay: coexistence of chronic cough and/or other lung diseases, having extrapulmonary or negative sputum smear TB, less severe and indifferent symptoms or absence of haemoptysis, poor health care infrastructure and seeking traditional and private practitioners first. As patients continue to go untreated, absent isolation, both components equally contribute to the infectious pool.

Our analysis revealed that the vicious circle of repeated visits at the same level is the core problem of diagnostic delay in most high endemic countries. TB is a rare disease, and more than 95% of patients with chronic cough seeking treatment at the level of primary healthcare do not have TB [43]. The delay in diagnosis on the part of health providers does not necessarily reflect inferior performance, but instead a lack of effective diagnostic tools and follow-up routines. Correct diagnosis requires both good training and available diagnostic facilities. The number of repetitions of this vicious cycle proved to be highly dependent on both the patient's beliefs and awareness of TB and the category of healthcare provider. In most countries, private practitioners are consulted first, and this pattern is significantly associated with a longer diagnostic delay. This pattern is also recognized as a source of bottleneck in low endemic countries. A New Zealand study observed that the first consulting doctor often did not perform an X-ray, ask about previous TB, or obtain a sputum smear – although the patients had classical symptoms [44]. The same observations were make by Ward et al in Australia [20]. Cough was treated symptomatically, and CXR were misdiagnosed.

A range of studies have shown that selection of a traditional practitioner for the first visit is associated with a prolonged delay in diagnosis [9, 10, 14, 26–29, 32, 36, 37]. In Yimer et al's study from Ethiopia, patients who first visited a qualified medical provider experienced a 21-day delay before initiation of treatment. Patients who first visited a traditional healthcare provider waited 15 days before first seeking healthcare, but the period from first visit to initiation of TB treatment was 4-fold greater [6]. These findings are supported by studies of The Gambia [32], Tanzania [29], and Penang [21].

Many studies describe a bottleneck in reaching the local unit of the NTP. Multiple studies observed poor access to the NTP as one of the main factors in delayed diagnosis [6, 8, 10, 14, 18, 23, 25, 27–30, 34, 42, 47, 48, 50]. In many high endemic countries, it appears crucial that a unit of the NTP is within a 1-day walking distance, as many patients have limited access to motorized vehicles. In addition to geographic distance, the studies identified several other barriers. One of the most important barriers is stigma [27]. Many patients were highly reluctant to visit the NTP facility, because it would mean disclosing to the public that they had TB. Even worse, in many countries, TB is so closely linked to HIV that patients fear they are revealing HIV status to their neighbors [37]. Also, many of the NTP personnel are unfriendly. Many patients feel deprived of both privacy and dignity. The widespread introduction of DOTS also means that patients must visit daily so that their consumption of medication can be directly observed; this is perceived as humiliating, time consuming, and a threat of a substantial loss of income [6, 51, 52]. A marginal farmer or a day laborer will often have to choose between treatment and placing food on the table for his family. Most of the studies from developing countries demonstrated a significant link between delayed diagnosis and poverty [7, 20, 21, 27, 28, 34, 37, 40, 47, 48].

Most of the studies in our review also demonstrate the nonspecific nature of symptoms and the disease's first natural history as a core problem [15, 18, 23, 31, 50, 53]. In the Gambia, TB is often misdiagnosed as malaria or viral infections [32].

Several studies also highlight the problem of self-treatment [6, 36, 42]. In the study in Pakistan, more than 50% of patients practiced self-treatment, and 42% first searched a pharmacy for their symptoms[27]. Many studies link this to the problem of stigma, in fact the unhappy triad of incomprehensive beliefs, low awareness, and stigma.

Conclusion

Our analysis is consistent with the findings of the WHO Eastern Mediterranean Region study. They concluded: "The private sector was the first choice for more than two-thirds of the patients. The main determinants of delay were: socio-demographic; economic; stigma; time to reach the health facility; seeking care from non-specialized individuals; and visiting more than one health care provider before diagnosis [3]." The core problem in delay of diagnosis and treatment seemed to be a vicious cycle of repeated visits at the same healthcare level, resulting in nonspecific antibiotic treatment and failure to access specialized TB services. Once generation of a specific diagnosis was in reach, TB treatment was initiated within a reasonable period of time.

References

  1. Dolin PJ, Raviglione MC, Kochi A: Global tuberculosis incidence and mortality during 1990-2000. Bull World Health Organ. 1994, 72 (2): 213-220.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. WHO: Global Tuberculosis Control: Surveillance, Planning, Financing: WHO report 2005. 2005, Geneva , World Health Organization (WHO/HTM/TB/2005.349),

    Google Scholar 

  3. Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC: Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. Jama. 1999, 282 (7): 677-686. 10.1001/jama.282.7.677.

    Article  CAS  PubMed  Google Scholar 

  4. Bjune G: Tuberculosis in the 21st century: an emerging pandemic?. Norsk Epidemiologi. 2005, 15 (2): 133-139.

    Google Scholar 

  5. Madebo T, Lindtjørn B: Delay in Treatment of Pulmonary Tuberculosis: An Analysis of Symptom Duration Among Ethiopian Patients. 1999, Medscape General Medicine , -[http://www.medscape.com/viewarticle/407989]

    Google Scholar 

  6. Yimer S, Bjune G, Alene G: Diagnostic and treatment delay among pulmonary tuberculosis patients in Ethiopia: a cross sectional study. BMC Infect Dis. 2005, 5: 112-10.1186/1471-2334-5-112.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lewis KE, Stephens C, Shahidi MM, Packe G: Delay in starting treatment for tuberculosis in east London. Commun Dis Public Health. 2003, 6 (2): 133-138.

    CAS  PubMed  Google Scholar 

  8. Pronyk RM, Makhubele MB, Hargreaves JR, Tollman SM, Hausler HP: Assessing health seeking behaviour among tuberculosis patients in rural South Africa. Int J Tuberc Lung Dis. 2001, 5 (7): 619-627.

    CAS  PubMed  Google Scholar 

  9. Rojpibulstit M, Kanjanakiritamrong J, Chongsuvivatwong V: Patient and health system delays in the diagnosis of tuberculosis in Southern Thailand after health care reform. Int J Tuberc Lung Dis. 2006, 10 (4): 422-428.

    CAS  PubMed  Google Scholar 

  10. Needham DM, Foster SD, Tomlinson G, Godfrey-Faussett P: Socio-economic, gender and health services factors affecting diagnostic delay for tuberculosis patients in urban Zambia. Trop Med Int Health. 2001, 6 (4): 256-259. 10.1046/j.1365-3156.2001.00709.x.

    Article  CAS  PubMed  Google Scholar 

  11. Lawn SD, Afful B, Acheampong JW: Pulmonary tuberculosis: diagnostic delay in Ghanaian adults. Int J Tuberc Lung Dis. 1998, 2 (8): 635-640.

    CAS  PubMed  Google Scholar 

  12. Franco J, Blanquer R, Flores J, Fernandez E, Plaza P, Nogueira JM: [Analysis of the diagnostic delay in tuberculosis]. Med Clin (Barc). 1996, 107 (12): 453-457.

    CAS  Google Scholar 

  13. Ngamvithayapong J, Yanai H, Winkvist A, Diwan V: Health seeking behaviour and diagnosis for pulmonary tuberculosis in an HIV-epidemic mountainous area of Thailand. Int J Tuberc Lung Dis. 2001, 5 (11): 1013-1020.

    CAS  PubMed  Google Scholar 

  14. Yamasaki-Nakagawa M, Ozasa K, Yamada N, Osuga K, Shimouchi A, Ishikawa N, Bam DS, Mori T: Gender difference in delays to diagnosis and health care seeking behaviour in a rural area of Nepal. Int J Tuberc Lung Dis. 2001, 5 (1): 24-31.

    CAS  PubMed  Google Scholar 

  15. Pirkis JE, Speed BR, Yung AP, Dunt DR, MacIntyre CR, Plant AJ: Time to initiation of anti-tuberculosis treatment. Tuber Lung Dis. 1996, 77 (5): 401-406. 10.1016/S0962-8479(96)90111-2.

    Article  CAS  PubMed  Google Scholar 

  16. Guneylioglu D, Yilmaz A, Bilgin S, Bayram U, Akkaya E: Factors affecting delays in diagnosis and treatment of pulmonary tuberculosis in a tertiary care hospital in Istanbul, Turkey. Med Sci Monit. 2004, 10 (2): CR62-7.

    PubMed  Google Scholar 

  17. Farah MG, Rygh JH, Steen TW, Selmer R, Heldal E, Bjune G: Patient and health care system delays in the start of tuberculosis treatment in Norway. BMC Infect Dis. 2006, 6: 33-10.1186/1471-2334-6-33.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Demissie M, Lindtjorn B, Berhane Y: Patient and health service delay in the diagnosis of pulmonary tuberculosis in Ethiopia. BMC Public Health. 2002, 2: 23-10.1186/1471-2458-2-23.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Odusanya OO, Babafemi JO: Patterns of delays amongst pulmonary tuberculosis patients in Lagos, Nigeria. BMC Public Health. 2004, 4: 18-10.1186/1471-2458-4-18.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Ward J, Siskind V, Konstantinos A: Patient and health care system delays in Queensland tuberculosis patients, 1985-1998. Int J Tuberc Lung Dis. 2001, 5 (11): 1021-1027.

    CAS  PubMed  Google Scholar 

  21. Hooi LN: Case-finding for pulmonary tuberculosis in Penang. Med J Malaysia. 1994, 49 (3): 223-230.

    CAS  PubMed  Google Scholar 

  22. Golub JE, Bur S, Cronin WA, Gange S, Baruch N, Comstock GW, Chaisson RE: Delayed tuberculosis diagnosis and tuberculosis transmission. Int J Tuberc Lung Dis. 2006, 10 (1): 24-30.

    CAS  PubMed  Google Scholar 

  23. Kiwuwa MS, Charles K, Harriet MK: Patient and health service delay in pulmonary tuberculosis pateints attending a referral hospital: a cross-sectional study. BMC Public Health. 2005, 5 (122):

  24. Altet Gomez MN, Alcaide Megias J, Canela Soler J, Mila Auge C, Jimenez Fuentes MA, de Souza Galvao ML, Solsona Peiro J: [Pulmonary symptomatic tuberculosis' diagnostic delay study]. Arch Bronconeumol. 2003, 39 (4): 146-152. 10.1157/13045947.

    Article  CAS  PubMed  Google Scholar 

  25. Rajeswari R, Chandrasekaran V, Suhadev M, Sivasubramaniam S, Sudha G, Renu G: Factors associated with patient and health system delays in the diagnosis of tuberculosis in South India. Int J Tuberc Lung Dis. 2002, 6 (9): 789-795.

    CAS  PubMed  Google Scholar 

  26. Steen TW, Mazonde GN: Pulmonary tuberculosis in Kweneng District, Botswana: delays in diagnosis in 212 smear-positive patients. Int J Tuberc Lung Dis. 1998, 2 (8): 627-634.

    CAS  PubMed  Google Scholar 

  27. WHO: Diagnostic and treatment delay in tuberculosis. 2006, Geneva , World Health Organisation

    Google Scholar 

  28. Bai LQ, Xiao SY: [Factors associated with diagnostic delay for patients with smear-positive pulmonary tuberculosis in rural Hunan, China]. Zhonghua Jie He He Hu Xi Za Zhi. 2004, 27 (9): 617-620.

    PubMed  Google Scholar 

  29. Wandwalo ER, Morkve O: Delay in tuberculosis case-finding and treatment in Mwanza, Tanzania. Int J Tuberc Lung Dis. 2000, 4 (2): 133-138.

    CAS  PubMed  Google Scholar 

  30. Long NH, Johansson E, Lonnroth K, Eriksson B, Winkvist A, Diwan VK: Longer delays in tuberculosis diagnosis among women in Vietnam. Int J Tuberc Lung Dis. 1999, 3 (5): 388-393.

    CAS  PubMed  Google Scholar 

  31. Mori T, Shimao T, Jin BW, Kim SJ: Analysis of case-finding process of tuberculosis in Korea. Tuber Lung Dis. 1992, 73 (4): 225-231. 10.1016/0962-8479(92)90091-W.

    Article  CAS  PubMed  Google Scholar 

  32. Lienhardt C, Rowley J, Manneh K, Lahai G, Needham D, Milligan P, McAdam KP: Factors affecting time delay to treatment in a tuberculosis control programme in a sub-Saharan African country: the experience of The Gambia. Int J Tuberc Lung Dis. 2001, 5 (3): 233-239.

    CAS  PubMed  Google Scholar 

  33. Anastasatu C, Burnea D, Avramescu D, Varachiu I: [Reasons for delayed diagnosis of pulmonary tuberculosis]. Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1989, 38 (4): 317-331.

    CAS  PubMed  Google Scholar 

  34. Okur E, Yilmaz A, Saygi A, Selvi A, Sungun F, Ozturk E, Dabak G: Patterns of delays in diagnosis amongst patients with smear-positive pulmonary tuberculosis at a teaching hospital in Turkey. Clin Microbiol Infect. 2006, 12 (1): 90-92. 10.1111/j.1469-0691.2005.01302.x.

    Article  CAS  PubMed  Google Scholar 

  35. Enkhbat S, Toyota M, Yasuda N, Ohara H: Differing influence on delays in the case-finding process for tuberculosis between general physicians and specialists in Mongolia. J Epidemiol. 1997, 7 (2): 93-98.

    Article  CAS  PubMed  Google Scholar 

  36. Liam CK, Tang BG: Delay in the diagnosis and treatment of pulmonary tuberculosis in patients attending a university teaching hospital. Int J Tuberc Lung Dis. 1997, 1 (4): 326-332.

    CAS  PubMed  Google Scholar 

  37. Xu B, Jiang QW, Xiu Y, Diwan VK: Diagnostic delays in access to tuberculosis care in counties with or without the National Tuberculosis Control Programme in rural China. Int J Tuberc Lung Dis. 2005, 9 (7): 784-790.

    CAS  PubMed  Google Scholar 

  38. Gagliotti C, Resi D, Moro ML: Delay in the treatment of pulmonary TB in a changing demographic scenario. Int J Tuberc Lung Dis. 2006, 10 (3): 305-309.

    CAS  PubMed  Google Scholar 

  39. Sherman LF, Fujiwara PI, Cook SV, Bazerman LB, Frieden TR: Patient and health care system delays in the diagnosis and treatment of tuberculosis. Int J Tuberc Lung Dis. 1999, 3 (12): 1088-1095.

    CAS  PubMed  Google Scholar 

  40. Asch S, Leake B, Anderson R, Gelberg L: Why do symptomatic patients delay obtaining care for tuberculosis?. Am J Respir Crit Care Med. 1998, 157 (4 Pt 1): 1244-1248.

    Article  CAS  PubMed  Google Scholar 

  41. Ouedraogo M, Kouanda S, Boncoungou K, Dembele M, Zoubga ZA, Ouedraogo SM, Coulibaly G: Treatment seeking behaviour of smear-positive tuberculosis patients diagnosed in Burkina Faso. Int J Tuberc Lung Dis. 2006, 10 (2): 184-187.

    CAS  PubMed  Google Scholar 

  42. Wang WB, Wang FD, Xu B, Zhu JF, Shen W, Xiao XR, Jiang QW: [A cost-effectiveness study on a case-finding program of tuberculosis through screening those suspects with chronic cough symptoms in the rich rural areas]. Zhonghua Liu Xing Bing Xue Za Zhi. 2006, 27 (10): 857-860.

    PubMed  Google Scholar 

  43. Calder L: Tuberculosis: reasons for diagnostic delay in Auckland. N Z Med J. 2000, 113 (1122): 483-485.

    CAS  PubMed  Google Scholar 

  44. Masjedi MR, Cheragvandi A, Hadian M, Velayati AA: Reasons for delay in the management of patients with pulmonary tuberculosis. East Mediterr Health J. 2002, 8 (2-3): 324-329.

    CAS  PubMed  Google Scholar 

  45. Sasaki Y, Yamagishi F, Yagi T, Yamatani H, Kuroda F, Shoda H: [A study of patient's and doctor's delay in patients with pulmonary tuberculosis discovered by visiting doctors with symptoms in particular on doctor's delay]. Kekkaku. 2000, 75 (9): 527-532.

    CAS  PubMed  Google Scholar 

  46. Chavez T: Demora en el Diagnóstico y su Correlato Clínico, Radiológico y Bacteriológico en TBC Pulmonar. Anales de la Facultad de Medicina Universidad Nacional Mayor de San Marcos. 1998, Vol. 59 (3): 166-177.

    Google Scholar 

  47. Saly S, Onozaki I, Ishikawa N: Decentralized DOTS shortens delay to TB treatment significantly in Cambodia. Kekkaku. 2006, 81 (7): 467-474.

    PubMed  Google Scholar 

  48. Nkhoma WA, Harries AD, Wiriama JJ: Pulmonary tuberculosis in Malawian adults: why the delay in diagnosis?. Med Quarterly J Med Assoc Malawi. 1988, 5: 22-23.

    Google Scholar 

  49. Tesena N, Chuin N, Supannawong P, Buphatrakul K: Delay in case finding in 6th zonal tuberculosis center. Thai J Tuberc Chest Dis. 1991, 12: 187-194.

    Google Scholar 

  50. Pungrassami P, Hirunayapa J, Tunsawai V, Pongpanich S, Petchborisut O: The study of patient's and doctor's delay of tuberculosis case-detection in TB Center Zone 12 Yala. Thai J Tuberc Chest Dis. 1993, 14: 73-83.

    Google Scholar 

  51. Niijima Y, Yamagishi F, Suzuki K, Yasuda J, Shirai T, Satoh N, Tougou N, Wakayama S, Ihara S: [Patient's delay and doctor's delay in the primary treatment cases of pulmonary tuberculosis detected by subjective symptoms]. Kekkaku. 1990, 65 (10): 609-613.

    CAS  PubMed  Google Scholar 

  52. Salaniponi FM, Harries AD, Banda HT, Kang'ombe C, Mphasa N, Mwale A, Upindi B, Nyirenda TE, Banerjee A, Boeree MJ: Care seeking behaviour and diagnostic processes in patients with smear-positive pulmonary tuberculosis in Malawi. Int J Tuberc Lung Dis. 2000, 4 (4): 327-332.

    CAS  PubMed  Google Scholar 

  53. Rodger A, Jaffar S, Paynter S, Hayward A, Carless J, Maguire H: Delay in the diagnosis of pulmonary tuberculosis, London, 1998-2000: analysis of surveillance data. Bmj. 2003, 326 (7395): 909-910. 10.1136/bmj.326.7395.909.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Chiang CY, Chang CT, Chang RE, Li CT, Huang RM: Patient and health system delays in the diagnosis and treatment of tuberculosis in Southern Taiwan. Int J Tuberc Lung Dis. 2005, 9 (9): 1006-1012.

    CAS  PubMed  Google Scholar 

  55. Deng HJ, Zheng YH, Zhang YY, Xu B: [Study on factors causing the delay of access to tuberculosis diagnosis and its influencing factors in migrating tuberculosis patients in Putuo district, Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi. 2006, 27 (4): 311-315.

    PubMed  Google Scholar 

  56. Gulbaran Z, Pretet S, Dusser D: [From first symptom to diagnosis and from diagnosis to treatment of tuberculosis: still a long delay]. Rev Pneumol Clin. 1996, 52 (1): 20-25.

    CAS  PubMed  Google Scholar 

  57. Sadiq H, Muynck AD: Health care seeking behavior of pulmonary tuberculosis patients visiting TB center Rawalpindi. J Pak Med Assoc. 2001, 51 (10): 10-16.

    CAS  PubMed  Google Scholar 

Pre-publication history

Download references

Acknowledgements

This study was supported by the Competence Centre for Imported and Tropical Diseases, Ullevål University Hospital and Center for Prevention of Global Infections (Faculty of Medicine, University of Oslo, Norwegian Institute of Public Health, and Norwegian Health Services Research).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dag Gundersen Storla.

Additional information

Competing interests

The author(s) declare that they have no competing interests.

Authors' contributions

DGS, SY and GAB all contributed to develop the review protocol, DGS and SY performed data collection and analysis. DGS wrote the manuscript, and all the three authors edited and approved it.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Storla, D.G., Yimer, S. & Bjune, G.A. A systematic review of delay in the diagnosis and treatment of tuberculosis. BMC Public Health 8, 15 (2008). https://doi.org/10.1186/1471-2458-8-15

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/1471-2458-8-15

Keywords