Adriamycin administered to eggs of white Leghorns distributes to the caudal portion of the embryo and foregut epithelium, inducing caudal regression, tracheal and pulmonary agenesis and tracheo-esophageal anamolies reminiscent of VATER association.

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This in-vitro investigation established an important paracrine loop involving the osteoblastic osteopontin which activates Nf1+/- osteoclasts with intrinsic bone resorption properties leading to osteopenia and osteoporosis.

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Delivery of human umbilical cord blood cells to neonatal rats with hypoxic-ischemic brain injury failed to attenuate the observed spatial memory deficits and volumetric reduction in the ipsilateral cerebral hemisphere, suggesting the need for further optimization.

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Edaravone, a free radical scavenger, administered within forty-eight hours after a hypoxic-ischemic brain injury in neonatal rats reduced neuronal cell apoptosis and 8-hydroxy-2'-deoxyguanosine expression.

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Mucolipidosis type IV, a neurodegenerative channelopathy, is caused by deficiency of TRPML1 which is a proton channel that prevents over acidification of lysosomal organelles. Fibroblasts from severely and mildly affected patients treated with Nigericin demonstrated a reduction, while transfection with the MCOLN1 wild type cDNA that codes for TRPML1, led to removal of most of the lipid storage in vesicles.

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Infliximab, an adoptive therapy used in refractory Kawasaki disease is effective in suppressing cytokine-mediated inflammation but fails to block local vasculitis.

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