Myrothenones A and B, Cyclopentenone Derivatives with Tyrosinase Inhibitory Activity from the Marine-Derived Fungus Myrothecium sp.

Xifeng Li; Min Kyung Kim; Uk Lee; Se-Kwon Kim; Jung Sook Kang; Hong Dae Choi; Byeng Wha Son

doi:10.1248/cpb.53.453

Communications to the Editor

Myrothenones A and B, Cyclopentenone Derivatives with Tyrosinase Inhibitory Activity from the Marine-Derived Fungus Myrothecium sp.

Xifeng Li, Min Kyung Kim, Uk Lee, Se-Kwon Kim, Jung Sook Kang, Hong Dae Choi, Byeng Wha Son

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Keywords: marine-derived fungus, Myrothecium sp., myrothenone, 6-n-pentyl-α-pyrone, trichodenone A, tyrosinase inhibitory activity

JOURNAL FREE ACCESS

2005 Volume 53 Issue 4 Pages 453-455

DOI https://doi.org/10.1248/cpb.53.453

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Abstract

New 3-amino-5-ethenylcyclopentenones, myrothenones A (4) and B (5), were isolated together with known 6-n-pentyl-α-pyrone (1), trichodenone A (2), and cyclonerodiol (3) from the marine algicolous fungus of genus of Myrothecium. The structure and absolute stereochemistry of the new compounds were established by spectral interpretation and X-ray analysis. Compounds 1 and 4 exhibited a tyrosinase inhibitory activity with IC₅₀ value of 0.8 and 6.6 μM, respectively, which are more active than kojic acid (IC₅₀, 7.7 μM) currently being used as a functional personal-care compound.

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