Metabolism of Barbaloin by Intestinal Bacteria

MASAO HATTORI; TOMOYUKI KANDA; YUE-ZHONG SHU; TERUAKI AKAO; KYOICHI KOBASHI; TSUNEO NAMBA

doi:10.1248/cpb.36.4462

MASAO HATTORI, TOMOYUKI KANDA, YUE-ZHONG SHU, TERUAKI AKAO, KYOICHI KOBASHI, TSUNEO NAMBA

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Keywords: aloe-emodin anthrone, barbaloin, intestinal bacteria, metabolism, purgative

JOURNAL FREE ACCESS

1988 Volume 36 Issue 11 Pages 4462-4466

DOI https://doi.org/10.1248/cpb.36.4462

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Abstract

The C-glucosyl bond of barbaloin, a major purgative principle of aloe, was cleaved with human intestinal bacteria under anaerobic conditions, yielding aloe-emodin anthrone and aloeemodin bianthrone. Fecal flora of humans had the most potent transforming activity but those of rats and mice had less or no activity.

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