Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
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cDNA Microarray Gene Expression Analysis and Toxicological Phenotype for Anticancer Drug
Gyoung-Jae LEEWan-Seon LEEKi-Seon JEONChan-Hwi UMYang-Suk KIMSeung-Jun KIMChang-Hyeon LEEHyun-Kyu YOONSeung Yong HWANGJoon-Suk PARKJae-Woong HWANGKyung-Sun KANGYong-Soon LEEMaeng-Sup KIMKum-Jin CHONChan-Dong YEOJong-Soo KANG
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2004 Volume 66 Issue 11 Pages 1339-1345

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Abstract

Toxicogenomics, the subdiscipline that merges genomics with toxicology, hold the promise to contributing toward the goal of elucidating mechanism by studying genomic profiling related with various drugs. The application of gene expression profiling technology to examine multiple genes and signaling pathways promises a significant advance in understanding the toxic mechanisms of various drugs and prediction of new drug candidate. Toxicogenomics is emerging field combining genomics and bioinformatics to identify and characterize mechanisms of toxicity of drug and various compounds. The principal hypothesis underlying on this field is that chemical-specific pattern of altered gene expression is related with each chemicals properties, especially toxicological property, and it will be revealed using high-density microarray analysis of sample from exposed organisms. So, in this study we compare the gene expression pattern of two anticancer drugs paclitaxel and orally absorbable paclitaxel, using the cDNA microarray. And from the result of this study, it is possible to provide the new possibility for genome-wide insight into mechanism of their anticancer activity and toxicological phenotype.

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© 2004 by the Japanese Society of Veterinary Science

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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