Hostname: page-component-7c8c6479df-8mjnm Total loading time: 0 Render date: 2024-03-29T06:28:37.678Z Has data issue: false hasContentIssue false

Heritability and Genome-Wide Linkage Scan of Subjective Happiness

Published online by Cambridge University Press:  21 February 2012

Meike Bartels*
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands; EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands. m.bartels@psy.vu.nl
Viatcheslav Saviouk
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Marleen H. M. de Moor
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Gonneke Willemsen
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Toos C. E. M. van Beijsterveldt
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Jouke-Jan Hottenga
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Eco J. C. de Geus
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Dorret I. Boomsma
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
*
*Address for correspondence: Meike Bartels, PhD, Department of Biological Psychology, room 2B-47, 1081 BT Amsterdam, The Netherlands.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Causes of individual differences in happiness, as assessed with the Subjective Happiness Scale, are investigated in a large of sample twins and siblings from the Netherlands Twin Register. Over 12,000 twins and siblings, average age 24.7 years (range 12 to 88), took part in the study. A genetic model with an age by sex design was fitted to the data with structural equation modeling in Mx. The heritability of happiness was estimated at 22% for males and 41% in females. No effect of age was observed. To identify the genomic regions contributing to this heritability, a genome-wide linkage study for happiness was conducted in sibling pairs. A subsample of 1157 offspring from 441 families was genotyped with an average of 371 micro-satellite markers per individual. Phenotype and genotype data were analyzed in MERLIN with multipoint variance component linkage analysis and age and sex as covariates. A linkage signal (logarithm of odds score 2.73, empirical p value 0.095) was obtained at the end of the long arm of chromosome 19 for marker D19S254 at 110 cM. A second suggestive linkage peak was found at the short arm of chromosome 1 (LOD of 2.37) at 153 cM, marker D1S534 (empirical p value of .209). These two regions of interest are not overlapping with the regions found for contrasting phenotypes (such as depression, which is negatively associated with happiness). Further linkage and future association studies are warranted.

Type
Articles
Copyright
Copyright © Cambridge University Press 2010