Chest
Original ResearchAsthmaCausal Direction Between Respiratory Syncytial Virus Bronchiolitis and Asthma Studied in Monozygotic Twins
Section snippets
Materials and Methods
The study was approved by the ethics committee of Copenhagen (KA-20060022) and by the Danish Data Protection Agency (J.nr. 2005-41-5163 and J.nr. 2005-2311-0121). The children were enrolled after written consent was obtained from the parents or guardians.
Results
During the period from January 1, 1994, to December 31, 2003, 12,349 twin pairs were born in Denmark. The proband-wise concordance rate of hospitalization for RSV bronchiolitis was significantly higher in MZ (0.66) than in dizygotic twin pairs (0.53), P = .02.20 Fifty-seven MZ twin pairs (26 boys) were discordant for RSV hospitalization (Fig 1). Nine pairs were unavailable because of death or address protection. Five pairs were excluded based on their hospital records because the RSV infection
Discussion
We found no difference within cohabiting MZ twin pairs discordant for hospitalization for RSV bronchiolitis in infancy on asthma prevalence, baseline lung function, bronchial responsiveness, biomarker of airway inflammation (Feno), and sensitization 7 years after such severe RSV bronchiolitis. Though a number of criticisms may be raised, including the small study population, it is noteworthy that no trends suggested a differential effect from severe RSV infection. Therefore a strong effect from
Acknowledgments
Author contributions: Dr Poorisrisak: contributed to the planning of the visits, performed the experimental work, and contributed to the presentation, interpretation, and discussion of the obtained data.
Dr Halkjaer: contributed to the planning of the visits, was involved in the experimental work, and contributed to the discussion of the obtained data.
Dr Thomsen: contributed to the formulation of the scientific problem, the methodology design, and discussion of the obtained data.
Dr Stensballe:
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