Chest
Selected Reports/SeriesOptical Coherence Tomography as an Adjunct to Flexible Bronchoscopy in the Diagnosis of Lung Cancer: A Pilot Study
Section snippets
Study Population
Subjects were enrolled at the University of Oklahoma Health Sciences Center from June 2009 to December 2009. Study inclusion criteria included subjects 18 to 99 years of age with the presence of an endobronchial mass seen on chest imaging and the need for flexible bronchoscopy with endobronchial biopsies. An arterial blood gas was obtained preprocedurally on all patients. Exclusion criteria included a Paco2 > 47 mm Hg, long-term oxygen therapy, unwillingness to undergo flexible bronchoscopy,
Results
Eight patients with endobronchial masses on chest imaging were screened during the study period. Five patients were found to be eligible and participated in the study. A single endobronchial mass was identified in each subject during flexible bronchoscopy. A total of 60 endobronchial OCT images and corresponding biopsy specimens were obtained from the five subjects: 30 from an endobronchial mass and 30 from areas of normal-appearing bronchial mucosa. A library of OCT images with their
Discussion
The objective of this pilot study was to determine if it is feasible to use conventional OCT imaging as an adjunct to flexible bronchoscopy in the evaluation of patients with suspected lung cancer. Although the use of OCT imaging during rigid bronchoscopy for tracheal lesions has been reported,8, 9 this is the first reported use of OCT imaging in the United States during flexible bronchoscopy for bronchial lesions. Our data show that OCT imaging can be used during flexible bronchoscopy to
Conclusion
Conventional OCT imaging during flexible bronchoscopy appears to be feasible in patients with endobronchial tumors. This is the first reported use of this technology during flexible bronchoscopy in the United States. OCT scan features of malignancy may include loss of normal landmarks in the bronchial epithelium and lamina propria. Further studies are needed to determine the diagnostic yield of OCT imaging in the evaluation of endobronchial lesions.
Acknowledgments
Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Other contributors: We thank Randall G. Michel, MD; Julie A. Stoner, PhD; and Paul V. Carlile, MD for their intellectual contributions to this study.
Additional Information: The e-Figures can be found in the Online Supplement at http://chestjournal.chestpubs.org/content/138/4/984/suppl/DC1.
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