Chest
Clinical Investigations: Inflammatory AirwaysErythromycin Inhibits Neutrophil Chemotaxis in Bronchoalveoli of Diffuse Panbronchiolitis
Section snippets
Patient Population
We evaluated neutrophil chemotactic activity (NCA) in 13 patients with DPB (10 men and 3 women; mean age 39.2Ā±4.9 years) who satisfied the diagnostic criteria for DPB set out by the Japanese Ministry of Health and Welfare. All the patients had the following clinical features: (1) symptoms of chronic cough with sputum production and exertional dyspnea, (2) physical signs of coarse crackles and rhonchi, (3) typical radiologic features on chest roentgenogram of diffuse nodular shadows and
Clinical Characteristics of Patients
Neutrophil chemotactic activity was measured in the pre- and post-EM treatment BAL fluid of the 13 DPB patients. As shown in Table 1, their mean duration of disease was 9.0Ā±1.9 years; the onset was insidious. Sputum cultures at the time of admission yielded Hemophilus influenzae in four patients (cases 6, 8, 10, and 11), Pseudomonas aeruginosa in three (cases 4, 9, and 13), Staphylococcus aureus in one (case 1), and normal flora in 5 (cases 2, 3, 5, 7, and 12). Erythromycin was administered to
Discussion
Diffuse panbronchiolitis is a chronic inflammatory disease that is manifested in a diffuse fashion in both lungs in the region of the respiratory bronchioles. Typical features of the lesions are thickening of the walls of the bronchioles, with infiltration of lymphocytes, plasma cells, and histiocytes; proliferation of lymphfollicles; accumulation of foamy cells within the wall and neighboring area; and extension of these inflammatory changes toward the peribronchiolar tissues.1, 2
The treatment
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Azithromycin is the answer in paediatric respiratory medicine, but what was the question?
2020, Paediatric Respiratory ReviewsCitation Excerpt :Trials of other macrolides followed, and it became clear that, although relapse was not uncommon, macrolide therapy was curative for many of these patients [2,3]. Benefit in DPB was associated with reductions in neutrophilic inflammation and neutrophil chemo-attractants [4,5]. The obvious similarities between DPB and cystic fibrosis (CF) led to investigators posing the question, āwill macrolides be beneficial in CF?ā
Bronchiolitis and Other Intrathoracic Airway Disorders
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth EditionClarithromycin ameliorates pulmonary inflammation induced by short term cigarette smoke exposure in mice
2015, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Our murine models with short-term CS exposure and clinical exacerbations of COPD and asthma share common phenotypes, including neutrophil accumulation into the lung, and up-regulation of neutrophil chemotactic chemokines. Although the molecular mechanisms and/or targets of CAM were not investigated in this study, previous studies indicated that administration of CAM as well as EM significantly reduced BAL neutrophilia and neutrophil chemotactic activities [27] and IL-8 [28] among patients with DPB. We demonstrated that CAM and EM inhibit gene expression of IL-8 [29].
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2013, Revue des Maladies Respiratoires ActualitesEffects of the aquatic contaminant human pharmaceuticals and their mixtures on the proliferation and migratory responses of the bioindicator freshwater ciliate Tetrahymena
2012, ChemosphereCitation Excerpt :Similarly, the Ī²-blockers metoprolol and propranolol but not timolol decreased the fMLF induced chemotaxis of neutrophils at 10ā8 M (Djanani et al., 2003). The iodinated X-ray contrast agent was also reported to inhibit PMN chemotaxis induced by fMLF at micromolar concentration possibly by interacting with the specific fMLF receptor (Levesque et al., 1992) as well as erythromycin, that reduced in vivo and in vitro neutrophil migration in inflammatory conditions (Oda et al., 1994). Interestingly, the strong chemoattractant potential of fMLF (Chtx.